ArticleAntioxidants (Basel, Switzerland)2016
Antioxidant Activity of Oat Proteins Derived Peptides in Stressed Hepatic HepG2 Cells.
Article in Antioxidants (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Food Protein-Derived Antioxidant Peptides: Molecular Mechanism, Stability and Bioavailability.Biomolecules · 2022Pooled it
- Rice Bran Proteins Extracted by Different Methods: Structural Properties and Antioxidant and Anti-Photoaging Activities of Their Hydrolysates.Antioxidants (Basel, Switzerland) · 2026Article
- Antioxidant Activity In Vitro and Protective Effects Against Lipopolysaccharide-Induced Oxidative Stress and Inflammation in RAW264.7 Cells ofFoods (Basel, Switzerland) · 2025Article
- Structural characterization of peroxyl radical oxidative products of antioxidant peptides from hydrolyzed proteins.Heliyon · 2024Article
- Impact of In Vitro Digestion on the Digestibility, Amino Acid Release, and Antioxidant Activity of Amaranth (Antioxidants (Basel, Switzerland) · 2023Article
- Palm Kernel Meal Protein Hydrolysates Enhance Post-Thawed Boar Sperm Quality.Animals : an open access journal from MDPI · 2023Article
- Study of the Total Antioxidant Capacity (TAC) in Native Cereal-Pulse Flours and the Influence of the Baking Process on TAC Using a Combined Bayesian and Support Vector Machine Modeling Approach.Foods (Basel, Switzerland) · 2023Article
- Transepithelial transport and cellular mechanisms of food-derived antioxidant peptides.Heliyon · 2022Review
- Identification and Characterization of Dipeptidyl Peptidase-IV Inhibitory Peptides from Oat Proteins.Foods (Basel, Switzerland) · 2022Article
- Dietary-Nutraceutical Properties of Oat Protein and Peptides.Frontiers in nutrition · 2022Review
- Antioxidant Peptides From Protein Hydrolysate of Marine Red AlgaeFrontiers in microbiology · 2022Article
- Composition of the Protein Ingredients from Insoluble Oat Byproducts Treated with Food-Grade Enzymes, Such as Amylase, Cellulose/Xylanase, and Protease.Foods (Basel, Switzerland) · 2021Article
- Antioxidant activity of SSeCAHK in HepG2 cells: a selenopeptide identified from selenium-enriched soybean protein hydrolysates.RSC advances · 2021Article
- Spent Hen Muscle Protein-Derived RAS Regulating Peptides Show Antioxidant Activity in Vascular Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Spent Hen Protein Hydrolysate with Good Gastrointestinal Stability and Permeability in Caco-2 Cells Shows Antihypertensive Activity in SHR.Foods (Basel, Switzerland) · 2020Article
- Chemical and Cellular Antioxidant Activities of In Vitro Digesta of Tilapia Protein and Its Hydrolysates.Foods (Basel, Switzerland) · 2020Article
- Immunomodulatory and Antioxidant Properties of Wheat Gluten Protein Hydrolysates in Human Peripheral Blood Mononuclear Cells.Nutrients · 2020Article
- Article
- Identification and Active Evaluation of Antioxidant Peptides from Protein Hydrolysates of Skipjack Tuna (Antioxidants (Basel, Switzerland) · 2019Article
- Analysis of antioxidant effect of two tripeptides isolated from fermented grains (Jiupei) and the antioxidative interaction with 4-methylguaiacol, 4-ethylguaiacol, and vanillin.Food science & nutrition · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to determine, for the first time, antioxidant activities of seven peptides (P1-P7) derived from hydrolysis of oat proteins in a cellular model. In the oxygen radical absorbance capacity (ORAC) assay, it was found that P2 had the highest radical scavenging activity (0.67 ± 0.02 µM Trolox equivalent (TE)/µM peptide) followed by P5, P3, P6, P4, P1, and P7 whose activities were between 0.14-0.61 µM TE/µM). In the hepatic HepG2 cells, none of the peptides was cytotoxic at 20-300 µM. In addition to having the highest ORAC value, P2 was also the most protective (29% increase in cell viability) against 2,2'-azobis(2-methylpropionamidine) dihydrochloride -induced oxidative stress. P1, P6, and P7 protected at a lesser extent, with an 8%-21% increase viability of cells. The protection of cells was attributed to several factors including reduced production of intracellular reactive oxygen species, increased cellular glutathione, and increased activities of three main endogenous antioxidant enzymes.
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Registered trials
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