ReviewHistochemistry and cell biology2016
Chemosensory epithelial cells in the urethra: sentinels of the urinary tract.
Review in Histochemistry and cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Innate immune functions of bitter taste receptors across physiological systems.Journal of translational medicine · 2026Review
- Postoral receptors and alimentary taste: implications for energy intake and appetite.Chemical senses · 2025Review
- Research and progress on the mechanism of lower urinary tract neuromodulation: a literature review.PeerJ · 2024Review
- Thymic tuft cells: potential "regulators" of non-mucosal tissue development and immune response.Immunologic research · 2023Review
- Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.Annual review of pathology · 2023Review
- Novel protocol to observe the intestinal tuft cell using transmission electron microscopy.Biology open · 2022Article
- Oral Microbiota-Host Interaction Mediated by Taste Receptors.Frontiers in cellular and infection microbiology · 2022Review
- Cellular and functional heterogeneity of the airway epithelium.Mucosal immunology · 2021Review
- Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice.Cell and tissue research · 2021Article
- Neurophysiological control of urinary bladder storage and voiding-functional changes through development and pathology.Pediatric nephrology (Berlin, Germany) · 2021Review
- Gingival solitary chemosensory cells are immune sentinels for periodontitis.Nature communications · 2019Article
- Potential Role of Extracellular ATP Released by Bacteria in Bladder Infection and Contractility.mSphere · 2019Article
- Tuft Cells-Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry.Annual review of immunology · 2019Review
- Detection of intrinsic cholinergic system in the human lacrimal drainage system: evidence and potential implications.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018Article
- Role of neurogenic inflammation in local communication in the visceral mucosa.Seminars in immunopathology · 2018Review
- Immunohistochemical characterization of brush cells in the rat larynx.Journal of molecular histology · 2018Article
- Serotonergic paraneurones in the female mouse urethral epithelium and their potential role in peripheral sensory information processing.Acta physiologica (Oxford, England) · 2018Article
- ENaC in Cholinergic Brush Cells.Frontiers in cell and developmental biology · 2018Article
- Re-evaluation of glutamic acid (E 620), sodium glutamate (E 621), potassium glutamate (E 622), calcium glutamate (E 623), ammonium glutamate (E 624) and magnesium glutamate (E 625) as food additives.EFSA journal. European Food Safety Authority · 2017Article
- In focus in HCB: from cell biology to tissue structure and function.Histochemistry and cell biology · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A peculiar cell type of the respiratory and gastrointestinal epithelia, originally termed "brush cell" or "tuft cell" by electron microscopists because of its apical tuft of microvilli, utilizes the canonical bitter taste transduction cascade known from oropharyngeal taste buds to detect potential hazardous compounds, e.g. bacterial products. Upon stimulation, this cell initiates protective reflexes and local inflammatory responses through release of acetylcholine and chemokines. Guided by the understanding of these cells as sentinels, they have been newly discovered at previously unrecognized anatomical locations, including the urethra. Solitary cholinergic urethral cells express canonical taste receptors and are polymodal chemosensors for certain bitter substances, glutamate (umami) and uropathogenic Escherichia coli. Intraurethral bitter stimulation triggers cholinergic reflex activation of bladder detrusor activity, which is interpreted as cleaning flushing of the urethra. The currently known scenario suggests the presence of at least two more urethral chemosensory cell types: non-cholinergic brush cells and neuroendocrine serotonergic cells. The potential implications are enormous and far reaching, as these cells might be involved in monitoring and preventing ascending urinary tract infection and triggering of inappropriate detrusor activity. However, although appealing, this is still highly speculative, since the actual number of distinct chemosensory cell types needs to be finally clarified, as well as their embryological origin, developmental dynamics, receptor equipment, modes of signalling to adjacent nerve fibres and other cells, repertoire of chemo- and cytokines, involvement in pathogenesis of diseases and many other aspects.
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