← Metformin × glycemic control

Observational studyBMC cancer2016

Metformin use and its effect on survival in diabetic patients with advanced non-small cell lung cancer.

Oscar Arrieta et al.PubMed ↗Full text ↗Publisher ↗

  • Metformin uselooks good hereLower overall survival.Correlation only, not a test of it.
  • Proper glycemic controllooks good hereLower overall survival.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower glycemic control

−43%−64% to −10%

Bigger than 4 in 10 for glycemic control

As reported

HR 0.57, 95% CI 0.36–0.90

+4 more in the walkthrough ↓

Who was studied, and how

1,106people with type 2 diabetes, in this paper

Already taking metformin use, or nottheir own situation, not assigned

on metformin use
not on metformin use

Metformin use went with lower overall survival−47%

correlation, not a test

Already taking proper glycemic control, or nottheir own situation, not assigned

on proper glycemic control
improper glycemic control

Proper glycemic control went with lower overall survival−51%

correlation, not a test

the abstract, start to end

Both the use of metformin (HR 0.53, p < 0.0001 and HR 0.57, p = 0.017, respectively) and proper glycemic control (HR 0.49, p < 0.0001 and HR 0.40, p = 0.002, respectively) were …

… that both the use of metformin (HR 0.57 [95 % CI 0.36-0.90]; p = 0.017) …

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Overall survival (OS)metformin use vs no metformin use, in all patients
HR 0.53
Overall survival (OS)metformin use vs no metformin use, in diabetic patients
HR 0.57
Overall survival (OS)proper glycemic control vs improper glycemic control, in all patients
HR 0.49
Overall survival (OS)proper glycemic control vs improper glycemic control, in diabetic patients
HR 0.40
Glycemic control
HR 0.570.36–0.90
MetforminGlycemic controlAll-cause mortality
1 / 4

36 papers cite it

2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 27519177