← Statins × pharmacokinetics & dosing

SynthesisPloS one2016

Statin Use and the Risk of Parkinson's Disease: An Updated Meta-Analysis.

Shuang Bai et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedas reported · 513,209 people · 2016

Range includes no effect

No clear effect on pharmacokinetics & dosing

−23%−44% to +7%

Bigger than 5 in 10 on the map

As reported

RR 0.77, 95% CI 0.56–1.07

Not counted

Lowered pharmacokinetics & dosing

−19%−29% to −8%

Bigger than 4 in 10 on the map

As reported

RR 0.81, 95% CI 0.71–0.92

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with lower pharmacokinetics & dosing

−19%−29% to −8%

Bigger than 4 in 10 on the map

As reported

RR 0.81, 95% CI 0.71–0.92

Correlation, not cause

Went with lower pharmacokinetics & dosing

−29%−41% to −13%

Bigger than 6 in 10 on the map

As reported

RR 0.71, 95% CI 0.59–0.87

Correlation, not cause

Went with lower pharmacokinetics & dosing

−23%−38% to −3%

Bigger than 5 in 10 on the map

As reported

RR 0.77, 95% CI 0.62–0.97

+1 more in the walkthrough ↓

Six numbers in the abstract

the abstract, start to end

… a lower risk of PD, with a summary RR of 0.81 (95% CI 0.71-0.92).

… showed an inverse association (RR 0.71, 95% CI 0.59-0.87) between …

… the risk of PD almost significantly (RR 0.77, 95% CI 0.56-1.07).

… model, obtaining a summary RR of 0.81 (95% CI 0.71-0.92); that is, …

… of PD in both case-control studies (RR 0.77, 95% CI 0.62-0.97) and cohort …

… association with the risk of PD (RR 0.83, 95% CI 0.66-1.05; RR 0.61, 95% …

← favours treatmentfavours comparator →
could be chance
Pharmacokinetics & dosing
RR 0.810.71–0.92
Pharmacokinetics & dosing
RR 0.710.59–0.87
Pharmacokinetics & dosing
RR 0.770.56–1.07
Pharmacokinetics & dosing
RR 0.810.71–0.92
Pharmacokinetics & dosing
RR 0.770.62–0.97
Pharmacokinetics & dosing
RR 0.830.66–1.05
StatinsPharmacokinetics & dosing
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Full record →Abstract, authors, funding and every citing paper · PMID 27019096