Evidence map›Paper›PMID 26942445›Full record

Trial reportPloS one2016

Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects: A Randomized, Double-Blind, Parallel-Group Trial.

Anne Christin Meyer-Gerspach, Lucian Cajacob, Daniele Riva, Raphael Herzog, Juergen Drewe, Christoph Beglinger, Bettina K Wölnerhanssen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01875575 (Oral Glucose in Normal-weight and Obese Volunteers), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01875575 nacompletednot on this map

Oral Glucose in Normal-weight and Obese Volunteers

TypeinterventionalSponsorUniversity Hospital, Basel, SwitzerlandRan2013 to 2013Enrolled24ConditionsEndocrine System DiseasesArmsPlacebo, Glucose 25g, Glucose 10g
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Anne Christin Meyer-GerspachDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Lucian CajacobDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Daniele RivaDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Raphael HerzogDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Juergen DreweDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Christoph BeglingerDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
Bettina K WölnerhanssenDepartment of Biomedicine, Division of Gastroenterology, University Hospital Basel, Basel, Switzerland.
University Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe changes in blood glucose concentrations that result from an oral glucose challenge are dependent on the rate of gastric emptying, the rate of glucose absorption and the rate of insulin-driven metabolism that include the incretins, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1). The rate of insulin-driven metabolism is clearly altered in obese subjects, but it is controversial which of these factors is predominant. We aimed to quantify gastric emptying, plasma insulin, C-peptide, glucagon and glucose responses, as well as incretin hormone secretions in obese subjects and healthy controls during increasing glucose loads. SUBJECTS/

methodsThe study was conducted as a randomized, double-blind, parallel-group trial in a hospital research unit. A total of 12 normal weight (6 men and 6 women) and 12 non-diabetic obese (BMI > 30, 6 men and 6 women) participants took part in the study. Subjects received intragastric loads of 10 g, 25 g and 75 g glucose dissolved in 300 ml tap water.

resultsMain outcome measures were plasma GLP-1 and GIP, plasma glucagon, glucose, insulin, C-peptide and gastric emptying. The primary findings are: i) insulin resistance (P < 0.001) and hyperinsulinemia (P < 0.001); ii) decreased insulin disposal (P < 0.001); iii) trend for reduced GLP-1 responses at 75 g glucose; and iv) increased fasting glucagon levels (P < 0.001) in obese subjects.

conclusionsIt seems that, rather than changes in incretin secretion, fasting hyperglucagonemia and consequent hyperglycemia play a role in reduced disposal of insulin, contributing to hyperinsulinemia and insulin resistance.

trial registrationClinicalTrials.gov NCT01875575.

Indexed as

AdultBlood GlucoseBody Mass IndexBody WeightCase-Control StudiesC-PeptideDiabetes MellitusDouble-Blind MethodFemaleGastric EmptyingGastric Inhibitory PolypeptideGlucagonGlucagon-Like Peptide 1GlucoseHumansIncretinsBlood GlucoseC-PeptideGastric Inhibitory PolypeptideGlucagonGlucagon-Like Peptide 1GlucoseIncretinsInsulin

Identifiers

PMID26942445
PMCPMC4778796
OpenAlexW2291440908

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.