ArticleBMJ open2016
Associations with fracture in patients with diabetes: a nested case-control study.
Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Glucose-Lowering Drugs and Fracture Risk-a Systematic Review.Current osteoporosis reports · 2020Pooled it
- The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies.Oncotarget · 2017Pooled it
- Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019 · on this mapTrial
- Bridging the Gap in Diabetes and Fracture Care for Diverse Populations.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Associations of Serum Lipid Traits With Fracture and Osteoporosis: A Prospective Cohort Study From the UK Biobank.Journal of cachexia, sarcopenia and muscle · 2024Article
- Review
- SGLT2 inhibitor treatment is not associated with an increased risk of osteoporotic fractures when compared to GLP-1 receptor agonists: A nationwide cohort study.Frontiers in endocrinology · 2022Article
- The risk of major osteoporotic fractures with GLP-1 receptor agonists when compared to DPP-4 inhibitors: A Danish nationwide cohort study.Frontiers in endocrinology · 2022Article
- Risk Factors for Incident Fracture in Older Adults With Type 2 Diabetes: The Framingham Heart Study.Diabetes care · 2021Article
- Diabetes and fractures: new evidence of atypical femoral fractures?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Article
- Bone health in diabetes and prediabetes.World journal of diabetes · 2019Review
- Hypoglycaemia and type 1 diabetes are associated with an increased risk of fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Diabetes and bone.Osteoporosis and sarcopenia · 2019Review
- Type 1 Diabetes and Bone Fragility: Links and Risks.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Review
- Skeletal Fragility in Type 2 Diabetes Mellitus.Endocrinology and metabolism (Seoul, Korea) · 2018Review
- Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors.Drug safety · 2018Article
- The effect of insulin on bone mineral density among women with type 2 diabetes: a SWAN Pharmacoepidemiology study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Molecular Modulation of Osteoblasts and Osteoclasts in Type 2 Diabetes.Journal of diabetes research · 2018Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiabetes mellitus is associated with an increased risk of fractures, which is not fully explained by bone mineral density and common risk factors. The aim of this study is to investigate the association of medication and biochemical markers on the risk of fracture in a diabetes population. DESIGN AND
settingA nested case-control study was conducted based on Danish diabetes patients from The Danish National Hospital Discharge Registry.
participantsThe cases of the study were diabetes patients with a fracture (n=24,349), and controls were diabetes patients with no fracture (n=132,349). A total of 2627 diabetes patients were available for an analysis of patient characteristics, comorbidities, biochemical parameters and drug usage.
resultsAge (OR=1.02, 95% CI 1.01 to 1.04), diabetes duration (OR=1.06, 95% CI 1.02 to 1.09), a diagnosis of previous fracture (OR=2.20, 95% CI 1.55 to 3.11), an alcohol-related diagnosis (OR=2.94, 95% CI 1.76 to 4.91), total cholesterol level (OR=2.50, 95% CI 1.20 to 5.21) and the usage of antiepileptics (OR=2.12, 95% CI 1.39 to 3.59) all increased the odds of fracture. Low-density lipoprotein cholesterol levels decreased the odds of fracture (OR =0.34, 95% CI 0.16 to 0.74), where the level of 3.04-5.96 mmol/L was optimal with regard to fracture risk.
conclusionsLow-density lipoprotein cholesterol may improve our understanding of fractures in diabetes patients, and it may be added to current fracture risk models in diabetes patients.
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