← Insulin × adverse events & safety

TrialJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

Glycemic Control and Insulin Treatment Alter Fracture Risk in Older Men With Type 2 Diabetes Mellitus.

Richard H Lee et al.PubMed ↗Full text ↗Publisher ↗

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Went with higher adverse events & safety

+10%+7% to +12%

Bigger than 3 in 10 for adverse events & safety

As reported

HR 1.10, 95% CI 1.07–1.12

Correlation, not cause

Went with lower adverse events & safety

−12%−13% to −10%

Bigger than 4 in 10 for adverse events & safety

As reported

HR 0.88, 95% CI 0.87–0.90

Two numbers in the abstract

the abstract, start to end

… with greater risk of fracture (HR = 1.10, 95% CI 1.07-1.12).

… with decreased fracture risk (HR = 0.88, 95% CI 0.87-0.90).

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
HR 1.101.07–1.12
Adverse events & safety
HR 0.880.87–0.90
MetforminInsulinAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 31269274