ArticleObesity (Silver Spring, Md.)2016
Pre-existing differences and diet-induced alterations in striatal dopamine systems of obesity-prone rats.
Article in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Differences in ethanol drinking and nucleus accumbens opioid expression in male and female obesity-prone and obesity-resistant rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- Neural mechanisms linking Western diet consumption and cognitive impairment: a role for the vagus nerve.Clinical science (London, England : 1979) · 2026Review
- Exploring the link between hedonic overeating and prefrontal cortex dysfunction in the Ts65Dn trisomic mouse model.Cellular and molecular life sciences : CMLS · 2023Article
- Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats.Journal of neurochemistry · 2023Article
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Sex specific effects of "junk-food" diet on calcium permeable AMPA receptors and silent synapses in the nucleus accumbens core.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
- Sex and region-specific effects of high fat diet on PNNs in obesity susceptible rats.Physiology & behavior · 2020Article
- Effects of the estrous cycle and ovarian hormones on cue-triggered motivation and intrinsic excitability of medium spiny neurons in the Nucleus Accumbens core of female rats.Hormones and behavior · 2019Article
- 3D printed microfluidic device for online detection of neurochemical changes with high temporal resolution in human brain microdialysate.Lab on a chip · 2019Article
- Enhanced anxiety-like behavior emerges with weight gain in male and female obesity-susceptible rats.Behavioural brain research · 2019Article
- Functional and structural plasticity contributing to obesity: roles for sex, diet, and individual susceptibility.Current opinion in behavioral sciences · 2018Article
- Dietary influences on cognition.Physiology & behavior · 2018Article
- Cocaine and desipramine elicit distinct striatal noradrenergic and behavioral responses in selectively bred obesity-resistant and obesity-prone rats.Behavioural brain research · 2018Article
- Pattern of access determines influence of junk food diet on cue sensitivity and palatability.Appetite · 2018Article
- Eating 'Junk-Food' Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Homeostasis Meets Motivation in the Battle to Control Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Incubation of food craving is independent of macronutrient composition.Scientific reports · 2016Article
- Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity.Psychopharmacology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveInteractions between pre-existing differences in mesolimbic function and neuroadaptations induced by consumption of fatty, sugary foods are thought to contribute to human obesity. This study examined basal and cocaine-induced changes in striatal neurotransmitter levels without diet manipulation and D2 /D3 dopamine receptor-mediated transmission prior to and after consumption of "junk-foods" in obesity-prone and obesity-resistant rats.
methodsMicrodialysis and liquid chromatography-mass spectrometry were used to determine basal and cocaine-induced changes in neurotransmitter levels in real time with cocaine-induced locomotor activity. Sensitivity to the D2 /D3 dopamine receptor agonist quinpirole was examined before and after restricted junk-food exposure. Selectively bred obesity-prone and obesity-resistant rats were used.
resultsCocaine-induced locomotion was greater in obesity-prone rats versus obesity-resistant rats prior to diet manipulation. Basal and cocaine-induced increases in dopamine and serotonin levels did not differ. Obesity-prone rats were more sensitive to the D2 receptor-mediated effects of quinpirole, and junk-food produced modest alterations in quinpirole sensitivity in obesity-resistant rats.
conclusionsThese data show that mesolimbic systems differ prior to diet manipulation in susceptible versus resistant rats, and that consumption of fatty, sugary foods produce different neuroadaptations in these populations. These differences may contribute to enhanced food craving and an inability to limit food intake in susceptible individuals.
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