Evidence map›Paper›PMID 26739816›Full record

Trial reportDiabetologia2016

Metabolic and hormonal response to intermittent high-intensity and continuous moderate intensity exercise in individuals with type 1 diabetes: a randomised crossover study.

Lia Bally, Thomas Zueger, Tania Buehler, Ayse S Dokumaci, Christian Speck, Nicola Pasi, Carlos Ciller, Daniela Paganini, Katrin Feller, Hannah Loher and 5 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 30270019PMID 11842075PMID 1348845PMID 15161743PMID 16109070PMID 16644702other papers from this trial
Open the trial in the graph
NCT02068638 nacompletednot on this map

Exercise-related Fuel Metabolism and Glucose Stability in Individuals With Type 1 Diabetes Mellitus

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2014 to 2016Enrolled27ConditionsType 1 Diabetes Mellitus, Exercise, Hypoglycemia, Carbohydrate MetabolismArmsIHE first, CONT second, CONT first, IHE second, GLU first, GLU-FRU second, GLU-FRU first, GLU second
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Review
  11. Review
  12. Tailoring Exercise Prescription for Effective Diabetes Glucose Management.The Journal of clinical endocrinology and metabolism · 2025
    Review
  13. Hyperglycemia Suppresses Lactate Clearance During Exercise in Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Lia BallyDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Thomas ZuegerDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Tania BuehlerDepartment Clinical Research and Department of Radiology, University of Bern, Bern, Switzerland.
Ayse S DokumaciDepartment Clinical Research and Department of Radiology, University of Bern, Bern, Switzerland.
Christian SpeckDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Nicola PasiDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Carlos CillerDepartment of Radiology, University Hospital Centre and University of Lausanne, Lausanne, Switzerland.
Daniela PaganiniDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Katrin FellerDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Hannah LoherDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland.
Robin RossetDepartment of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Matthias WilhelmPreventive Cardiology and Sports Medicine, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Luc TappyDepartment of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Chris BoeschDepartment Clinical Research and Department of Radiology, University of Bern, Bern, Switzerland.
Christoph StettlerDivision of Endocrinology, Diabetes and Clinical Nutrition, Inselspital, Bern University Hospital, and University of Bern, CH-3010, Bern, Switzerland. christoph.stettler@insel.ch.
University Hospital of Bern · CHUniversity of Bern · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisTo investigate exercise-related fuel metabolism in intermittent high-intensity (IHE) and continuous moderate intensity (CONT) exercise in individuals with type 1 diabetes mellitus.

methodsIn a prospective randomised open-label cross-over trial twelve male individuals with well-controlled type 1 diabetes underwent a 90 min iso-energetic cycling session at 50% maximal oxygen consumption ([Formula: see text]), with (IHE) or without (CONT) interspersed 10 s sprints every 10 min without insulin adaptation. Euglycaemia was maintained using oral (13)C-labelled glucose. (13)C Magnetic resonance spectroscopy (MRS) served to quantify hepatocellular and intramyocellular glycogen. Measurements of glucose kinetics (stable isotopes), hormones and metabolites complemented the investigation.

resultsGlucose and insulin levels were comparable between interventions. Exogenous glucose requirements during the last 30 min of exercise were significantly lower in IHE (p = 0.02). Hepatic glucose output did not differ significantly between interventions, but glucose disposal was significantly lower in IHE (p < 0.05). There was no significant difference in glycogen consumption. Growth hormone, catecholamine and lactate levels were significantly higher in IHE (p < 0.05). CONCLUSIONS/

interpretationIHE in individuals with type 1 diabetes without insulin adaptation reduced exogenous glucose requirements compared with CONT. The difference was not related to increased hepatic glucose output, nor to enhanced muscle glycogen utilisation, but to decreased glucose uptake. The lower glucose disposal in IHE implies a shift towards consumption of alternative substrates. These findings indicate a high flexibility of exercise-related fuel metabolism in type 1 diabetes, and point towards a novel and potentially beneficial role of IHE in these individuals.

trial registrationClinicalTrials.gov NCT02068638

fundingSwiss National Science Foundation (grant number 320030_149321/) and R&A Scherbarth Foundation (Switzerland).

Indexed as

AdultBlood GlucoseCatecholaminesCross-Over StudiesDiabetes Mellitus, Type 1Energy MetabolismExerciseGrowth HormoneHumansLactic AcidMaleProspective StudiesYoung AdultBlood GlucoseCatecholaminesGrowth HormoneLactic AcidCarbohydrate metabolismExerciseHypoglycaemiaMetabolic physiology in vivo

Identifiers

PMID26739816
OpenAlexW2224086740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.