ArticleScientific reports2015
Lactic Acid Bacteria Protects Caenorhabditis elegans from Toxicity of Graphene Oxide by Maintaining Normal Intestinal Permeability under different Genetic Backgrounds.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
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- The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles.Nanoscale advances · 2023Review
- Lactic Acid Bacteria Strains Used as Starters for Kimchi Fermentation Protect the Disruption of Tight Junctions in the Caco-2 Cell Monolayer Model.Journal of microbiology and biotechnology · 2022Article
- Probiotics Interactions and the Modulation of Major Signalling Pathways in Host Model OrganismIndian journal of microbiology · 2021Review
- The TGF-β ligand DBL-1 is a key player in a multifaceted probiotic protection against MRSA in C. elegans.Scientific reports · 2021Article
- Heat-TreatedAntioxidants (Basel, Switzerland) · 2021Article
- Physiological effect of colloidal carbon quantum dots onRSC advances · 2021Article
- Article
- Engineering the surface of graphene oxide with bovine serum albumin for improved biocompatibility inNanoscale advances · 2020Article
- Synthesis and Physicochemical Transformations of Size-Sorted Graphene Oxide during Simulated Digestion and Its Toxicological Assessment against an In Vitro Model of the Human Intestinal Epithelium.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Bottom-Up Approaches to Synthetic Cooperation in Microbial Communities.Life (Basel, Switzerland) · 2019Review
- Potential genetic damage to nematode offspring following exposure to triclosan during pregnancy.Molecular medicine reports · 2017Article
- Combination of Metabolomic and Proteomic Analysis Revealed Different Features amongFrontiers in microbiology · 2017Article
- Wnt Ligands Differentially Regulate Toxicity and Translocation of Graphene Oxide through Different Mechanisms in Caenorhabditis elegans.Scientific reports · 2016Article
- A mir-231-Regulated Protection Mechanism against the Toxicity of Graphene Oxide in Nematode Caenorhabditis elegans.Scientific reports · 2016Article
- Biological effects, translocation, and metabolism of quantum dots in the nematodeToxicology research · 2016Review
- Metallothioneins act downstream of insulin signaling to regulate toxicity of outdoor fine particulate matter (PMToxicology research · 2016Article
- Intestinal Insulin Signaling Encodes Two Different Molecular Mechanisms for the Shortened Longevity Induced by Graphene Oxide in Caenorhabditis elegans.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Lactic acid bacteria (LAB) is safe and useful for food and feed fermentation. We employed Caenorhabditis elegans to investigate the possible beneficial effect of LAB (Lactobacillus bulgaricus) pretreatment against toxicity of graphene oxide (GO) and the underlying mechanisms. LAB prevented GO toxicity on the functions of both primary and secondary targeted organs in wild-type nematodes. LAB blocked translocation of GO into secondary targeted organs through intestinal barrier by maintaining normal intestinal permeability in wild-type nematodes. Moreover, LAB prevented GO damage on the functions of both primary and secondary targeted organs in exposed nematodes with mutations of susceptible genes (sod-2, sod-3, gas-1, and aak-2) to GO toxicity by sustaining normal intestinal permeability. LAB also sustained the normal defecation behavior in both wild-type nematodes and nematodes with mutations of susceptible genes. Therefore, the beneficial role of LAB against GO toxicity under different genetic backgrounds may be due to the combinational effects on intestinal permeability and defecation behavior. Moreover, the beneficial effects of LAB against GO toxicity was dependent on the function of ACS-22, homologous to mammalian FATP4 to mammalian FATP4. Our study provides highlight on establishment of pharmacological strategy to protect intestinal barrier from toxicity of GO.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.