ArticleNature communications2015
Formation of oligopeptides in high yield under simple programmable conditions.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Article
- Functional abiotic metabolite assembly hypothesis for the early events in the origin of life.Nature communications · 2026Review
- From Mineral Surfaces to Peptides: Hydroxyapatite-Based Platforms for Surface-Mediated Prebiotic Synthesis.International journal of molecular sciences · 2026Review
- Prebiotic β-Strand Peptides May Be a Plausible Solution to the Protocell Permeability Problem.Journal of molecular evolution · 2026Review
- Proteinoid Computing on Olivine Substrates.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Experimental and Computational Simulation of the Prebiotic Peptide Bond Formation Driven by Wet-Dry Cycles and Gamma Ionizing Radiation: An Insight into Molecular Evolution.Journal of molecular evolution · 2026Article
- Stringent selection on kinetics of condensation reactions: early steps in chemical evolution.Physical chemistry chemical physics : PCCP · 2026Article
- Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly.Journal of the American Chemical Society · 2026Article
- Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification.ACS bio & med chem Au · 2025Article
- Protopeptide backbone affects assembly in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Prebiotic Peptide Synthesis: How Did Longest Peptide Appear?Journal of molecular evolution · 2025Review
- Evolution of complex chemical mixtures reveals combinatorial compression and population synchronicity.Nature chemistry · 2025Article
- Prebiotic formation of thioesters via cyclic anhydrides as a key step in the emergence of metabolism.Scientific reports · 2025Article
- Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates.Nature communications · 2025Article
- Enhanced Oligopeptide and Free Tryptophan Release from Chickpea and Lentil Proteins: A Comparative Study of Enzymatic Modification with Bromelain, Ficin, and Papain.Plants (Basel, Switzerland) · 2024Article
- On the Roles of Protein Intrinsic Disorder in the Origin of Life and Evolution.Life (Basel, Switzerland) · 2024Review
- Phosphoric acid salts of amino acids as a source of oligopeptides on the early Earth.Communications chemistry · 2024Article
- Origins of Life: The Protein Folding Problem all over again?Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- From Zero to Hero: The Cyanide-Free Formation of Amino Acids and Amides from Acetylene, Ammonia and Carbon Monoxide in Aqueous Environments in a Simulated Hadean Scenario.Life (Basel, Switzerland) · 2024Article
- Qualitative Monitoring of Proto-Peptide Condensation by Differential FTIR Spectroscopy.ACS earth & space chemistry · 2024Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many high-yielding reactions for forming peptide bonds have been developed but these are complex, requiring activated amino-acid precursors and heterogeneous supports. Herein we demonstrate the programmable one-pot dehydration-hydration condensation of amino acids forming oligopeptide chains in around 50% yield. A digital recursive reactor system was developed to investigate this process, performing these reactions with control over parameters such as temperature, number of cycles, cycle duration, initial monomer concentration and initial pH. Glycine oligopeptides up to 20 amino acids long were formed with very high monomer-to-oligomer conversion, and the majority of these products comprised three amino acid residues or more. Having established the formation of glycine homo-oligopeptides, we then demonstrated the co-condensation of glycine with eight other amino acids (Ala, Asp, Glu, His, Lys, Pro, Thr and Val), incorporating a range of side-chain functionality.
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