← Statins × all-cause mortality

TrialOphthalmology2015

The Association of Statin Use with Age-Related Macular Degeneration Progression: The Age-Related Eye Disease Study 2 Report Number 9.

Shaza N Al-Holou et al.PubMed ↗Full text ↗Publisher ↗

  • Statin useno clear effectNo clear link with progression to late AMD.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation · may be no link

No clear link with progression to late AMD

−19%−45% to +20%

statin use vs no statin use

Bigger than 6 in 10 for all-cause mortality

As reported

HR 0.81, 95% CI 0.55–1.20

Correlation · may be no link

No clear link with progression to late AMD

+8%−17% to +41%

statin use vs no statin use

Bigger than 2 in 10 for all-cause mortality

As reported

HR 1.08, 95% CI 0.83–1.41

Who was studied, and how

3,791people with cardiovascular disease, in this paper

Already taking statin use, or nottheir own situation, not assigned

on statin use
not on statin use

No clear link with progression to late AMD−19%

correlation, not a test

the abstract, start to end

… was not statistically significant (HR, 0.81; 95% CI, 0.55-1.20; P = 0.29).

… to late AMD (hazard ratio [HR], 1.08; 95% confidence interval [CI], …

← favours treatmentfavours comparator →
could be chance
Progression to late AMDstatin use vs no statin use
HR 0.810.55–1.20
Progression to late AMDstatin use vs no statin use
HR 1.080.83–1.41
StatinsAll-cause mortality
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Full record →Abstract, authors, funding and every citing paper · PMID 26435335