ArticleThe Journal of nutrition2015
Urinary Phytoestrogens Are Associated with Subtle Indicators of Semen Quality among Male Partners of Couples Desiring Pregnancy.
Article in The Journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Effect ofLife (Basel, Switzerland) · 2026Article
- Urinary isoflavone concentrations and semen parameters of Japanese men seeking fertility treatment.Asian journal of andrology · 2026Article
- Traditional and Domestic Cooking Dramatically Reduce Estrogenic Isoflavones in Soy Foods.Foods (Basel, Switzerland) · 2024Article
- The Role of Genistein in Mammalian Reproduction.Molecules (Basel, Switzerland) · 2023Review
- Intake of soy products and soy isoflavones in relation to ovarian reserve.Fertility and sterility · 2023Article
- Improved Food-Processing Techniques to Reduce Isoflavones in Soy-Based Foodstuffs.Foods (Basel, Switzerland) · 2023Article
- Phytoestrogens and Health Effects.Nutrients · 2023Review
- Estrogenic Pastures: A Source of Endocrine Disruption in Sheep Reproduction.Frontiers in endocrinology · 2022Review
- New Evaluation of Isoflavone Exposure in the French Population.Nutrients · 2019Article
- Exposome-wide association study of semen quality: Systematic discovery of endocrine disrupting chemical biomarkers in fertility require large sample sizes.Environment international · 2019Article
- The Bioprotective Effects of Polyphenols on Metabolic Syndrome against Oxidative Stress: Evidences and Perspectives.Oxidative medicine and cellular longevity · 2019Review
- Toward Capturing the Exposome: Exposure Biomarker Variability and Coexposure Patterns in the Shared Environment.Environmental science & technology · 2018Article
- Endocrine disruption by dietary phyto-oestrogens: impact on dimorphic sexual systems and behaviours.The Proceedings of the Nutrition Society · 2017Review
- EDCs Mixtures: A Stealthy Hazard for Human Health?Toxics · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPhytoestrogens have been associated with subtle hormonal changes, although effects on male fecundity are largely unknown.
objectiveWe evaluated associations between male urinary phytoestrogen (isoflavone and lignan) concentrations and semen quality.
methodsThis study was a prospective cohort study of 501 male partners of couples desiring pregnancy and discontinuing contraception. Each participant provided up to 2 semen samples that were analyzed for 35 semen quality endpoints the following day. Linear mixed-effects models were used to estimate associations between baseline urinary phytoestrogen concentrations and semen quality parameters, adjusted for age, body mass index (BMI), research site, and serum lipid and cotinine concentrations.
resultsMost associations between urinary phytoestrogens and semen quality parameters were null. However, select individual phytoestrogens were associated with semen quality parameters, with associations dependent on the class of phytoestrogens and modified by BMI. Specifically, genistein and daidzein were associated with a lower percentage of normal sperm and increased abnormalities in semen morphology, with reduced associations observed as BMI increased (P < 0.05) [percentages (95% CIs) of normal morphology by WHO traditional criteria: genistein, main effect: -5.61% (-9.42%, -1.79%); interaction: 0.19% (0.06%, 0.31%) per log unit increase; daidzein, main effect: -5.35% (-9.36%, -1.34%); interaction: 0.18% (0.05%, 0.32%) per log unit increase]. Enterolactone was associated with fewer abnormalities in semen morphometry and morphology and decreased DNA fragmentation, with reduced associations observed as BMI increased (P < 0.05) [percentages (95% CIs) of abnormalities in the neck and midpiece: enterolactone, main effect: -3.35% (-6.51%, -0.19%); interaction: 0.11% (0.01%, 0.21%) per log unit increase].
conclusionsThese results suggest that male urinary phytoestrogen concentrations characteristic of the US population may be associated with subtle indicators of male fecundity and semen quality but were not associated with couple fecundity.
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