ArticleBiomedical reports2015
Glucose plus metformin compared with glucose alone on β-cell function in mouse pancreatic islets.
Article in Biomedical reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Metformin Preserves Insulin Secretion in Pancreatic β-cells through FGF21/Akt PathwayCombinatorial chemistry & high throughput screening · 2024Article
- The development and benefits of metformin in various diseases.Frontiers of medicine · 2023Review
- Sex differences in islet stress responses support female β cell resilience.Molecular metabolism · 2023Article
- Article
- Metabolic Adaptions/Reprogramming in Islet Beta-Cells in Response to Physiological Stimulators-What Are the Consequences.Antioxidants (Basel, Switzerland) · 2022Review
- Effect ofJournal of diabetes and metabolic disorders · 2021Article
- Metformin and Systemic Metabolism.Trends in pharmacological sciences · 2020Review
- Metformin-induced autophagy and irisin improves INS-1 cell function and survival in high-glucose environment via AMPK/SIRT1/PGC-1α signal pathway.Food science & nutrition · 2019Article
- Metformin Reduces Lipotoxicity-Induced Meta-Inflammation inJournal of diabetes research · 2019Article
- Metformin, beta-cell development, and novel processes following beta-cell ablation in zebrafish.Endocrine · 2018Article
- Protective effect of metformin on toxicity of butyric acid and arsenic in isolated liver mitochondria and langerhans islets in male mice: anIranian journal of basic medical sciences · 2017Article
- Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: reversal of such metabolic defects by metformin.Apoptosis : an international journal on programmed cell death · 2017Article
- Metformin modulates apoptosis and cell signaling of human podocytes under high glucose conditions.Journal of nephrology · 2016Article
- Pancreatic regulation of glucose homeostasis.Experimental & molecular medicine · 2016Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metformin is currently the first drug of choice for treatment of type II diabetes. The primary function of metformin is to decrease hepatic glucose production mainly by inhibiting gluconeogenesis. The aim of the present study was to investigate the effects of glucose alone (control groups) and glucose and metformin (treatment groups) on pancreatic islets functions. Pancreatic islets were isolated by collagenase digestion and incubated for 24 or 48 h in RPMI-1640 containing 5 mmol/l glucose (control groups 1 and 2, respectively) or 24 h with 25 mmol/l glucose (control group 3) and 15 µmol/l metformin (treatment groups 1, 2 and 3, corresponding to the control groups, respectively). Subsequently, the rate of insulin output from islets, pancreatic and duodenal homeobox 1 (
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