ArticleMolecules (Basel, Switzerland)2015
Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cytotoxicity-guided isolation of elatostemanosides I-VI fromRSC advances · 2025Article
- Comprehensive Characterization of Phytochemical Composition, Membrane Permeability, and Antiproliferative Activity ofInternational journal of molecular sciences · 2024Article
- Article
- Provenance and family variations in early growth of Manchurian walnut (Juglans mandshurica Maxim.) and selection of superior families.PloS one · 2024Article
- Walnut Kernel Oil and Defatted Extracts Enhance Mesenchymal Stem Cell Stemness and Delay Senescence.Molecules (Basel, Switzerland) · 2023Article
- 2-Methoxyjuglone, a Promising Bioactive Compound for Pharmaceutical and Agricultural Purposes: A Review.Current medical science · 2022Review
- Green walnut husk extracts Proliferation and Migration in Gastric Cancer.Journal of Cancer · 2022Article
- Genetic Diversity ofFrontiers in plant science · 2022Article
- The Advantage of Automatic Peer-Reviewing ofMolecules (Basel, Switzerland) · 2021Article
- Dependence of the Ripeness Stage on the Antioxidant and Antimicrobial Properties of Walnut (Molecules (Basel, Switzerland) · 2021Article
- Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma.Acta pharmaceutica Sinica. B · 2020Article
- Review
- A Comprehensive Review on the Chemical Constituents and Functional Uses of Walnut (International journal of molecular sciences · 2019Review
- Transthyretin Amyloid Fibril Disrupting Activities of Extracts and Fractions fromMolecules (Basel, Switzerland) · 2019Article
- Chemical Constituents of the Ethyl Acetate Extract from Diaphragma juglandis Fructus and Their Inhibitory Activity on Nitric Oxide Production In Vitro.Molecules (Basel, Switzerland) · 2017Article
- Enantioselective Separation of 4,8-DHT and Phytotoxicity of the Enantiomers on Various Plant Species.Molecules (Basel, Switzerland) · 2016Article
- Cytotoxic Compounds from Juglans sinensis Dode Display Anti-Proliferative Activity by Inducing Apoptosis in Human Cancer Cells.Molecules (Basel, Switzerland) · 2016Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-seven naphthoquinones and their derivatives, including four new naphthalenyl glucosides and twenty-three known compounds, were isolated from green walnut husks, which came from Juglans mandshurica Maxim. The structures of four new naphthalenyl glucosides were elucidated based on extensive spectroscopic analyses. All of these compounds were evaluated for their cytotoxic activities against the growth of human cancer cells lines HepG-2 by MTT [3-(4,5-dimethylthiazo l-2-yl)-2,5 diphenyl tetrazolium bromide] assay. The results were shown that most naphthoquinones in an aglycone form exhibited better cytotoxicity in vitro than naphthalenyl glucosides with IC50 values in the range of 7.33-88.23 μM. Meanwhile, preliminary structure-activity relationships for these compounds were discussed.
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