ArticleProceedings of the National Academy of Sciences of the United States of America2015
Expanded metabolic versatility of ubiquitous nitrite-oxidizing bacteria from the genus Nitrospira.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers, 1 of them a synthesis that pooled it.
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Who cites it
182 citing papers in PubMed, 1 synthesis or guideline pooled it, 542 citations in OpenAlex.
- How low can they go? Aerobic respiration by microorganisms under apparent anoxia.FEMS microbiology reviews · 2022Pooled it
- Linking Abundance and Activity of Ammonia-Oxidising Bacteria and Archaea in an Agriculturally Impacted First-Order Stream.Environmental microbiology · 2026Article
- Comparative physiological and genomic characterization of a novelApplied and environmental microbiology · 2026Article
- Cultivation-Based Detection of a Novel High-GC Nitrospira Derived From the Argentinian Copahue Volcano Area.Environmental microbiology · 2026Article
- Seasonal and Source-Associated Microbiome Dynamics in Brazilian Drinking Water.Microbial ecology · 2026Article
- Article
- Kinetic plasticity of nitrite-oxidizing bacteria containing cytoplasmic nitrite oxidoreductase.The ISME journal · 2026Article
- Elevated temperature simulating heatwaves restructures active nitrifying communities and associated viruses in tidal flats and agricultural soils.The ISME journal · 2026Article
- Unique phylogenies and metabolic adaptations of novel lineage III and comammoxISME communications · 2026Article
- Metabolic potential and contributions of ammonia-oxidizing microorganisms and complete ammonia oxidizers to soil nitrification in upland soils of northern China.ISME communications · 2026Article
- Functional diversity in bacterial communities of an integrated constructed wetland used forFrontiers in microbiology · 2026Article
- Floodplain nitrifiers harbor the genetic potential for utilizing a wide range of organic nitrogen compounds.mSystems · 2025Article
- Genomics and physiological characterizations of an acidotolerant nitrite-oxidizingApplied and environmental microbiology · 2025Article
- Clear niche partitioning of nitrite-oxidizing bacteria from the bottom and the slope of Mariana Trench.Microbiome · 2025Article
- Substrate Effect on the Contribution of Ammonium and Urea to Marine Nitrification and Nitrous Oxide Production.Environmental microbiology · 2025Article
- Unusual Plastoquinones in Non-Phototrophic Nitrifying Bacteria.Environmental microbiology reports · 2025Article
- Impact of Sugarcane-Pumpkin Intercropping on Soil Microbial Diversity.Microorganisms · 2025Article
- Nitrate-Nitrite Interplay in the Nitrogen Biocycle.Molecules (Basel, Switzerland) · 2025Review
- Wheat Yield, N Use Efficiency, Soil Properties, and Soil Bacterial Community as Affected by Long-Term Straw Incorporation and Manure Under Wheat-Summer Maize Cropping System in Southern Shanxi Province, China.Plants (Basel, Switzerland) · 2025Article
- The Effects of Iron-Bearing Minerals on the Community Diversity and Physiological Activity of Prokaryotic Microorganisms in Pit Mud Used for Strong-FlavorFoods (Basel, Switzerland) · 2025Article
122 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Nitrospira are a diverse group of nitrite-oxidizing bacteria and among the environmentally most widespread nitrifiers. However, they remain scarcely studied and mostly uncultured. Based on genomic and experimental data from Nitrospira moscoviensis representing the ubiquitous Nitrospira lineage II, we identified ecophysiological traits that contribute to the ecological success of Nitrospira. Unexpectedly, N. moscoviensis possesses genes coding for a urease and cleaves urea to ammonia and CO2. Ureolysis was not observed yet in nitrite oxidizers and enables N. moscoviensis to supply ammonia oxidizers lacking urease with ammonia from urea, which is fully nitrified by this consortium through reciprocal feeding. The presence of highly similar urease genes in Nitrospira lenta from activated sludge, in metagenomes from soils and freshwater habitats, and of other ureases in marine nitrite oxidizers, suggests a wide distribution of this extended interaction between ammonia and nitrite oxidizers, which enables nitrite-oxidizing bacteria to indirectly use urea as a source of energy. A soluble formate dehydrogenase lends additional ecophysiological flexibility and allows N. moscoviensis to use formate, with or without concomitant nitrite oxidation, using oxygen, nitrate, or both compounds as terminal electron acceptors. Compared with Nitrospira defluvii from lineage I, N. moscoviensis shares the Nitrospira core metabolism but shows substantial genomic dissimilarity including genes for adaptations to elevated oxygen concentrations. Reciprocal feeding and metabolic versatility, including the participation in different nitrogen cycling processes, likely are key factors for the niche partitioning, the ubiquity, and the high diversity of Nitrospira in natural and engineered ecosystems.
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