Evidence map›Paper›PMID 26265791›Full record

ArticleClinical science (London, England : 1979)2015

Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity.

Lina Zhao, Zhuo Fu, Jing Wu, Kevin W Aylor, Eugene J Barrett, Wenhong Cao, Zhenqi Liu

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical science (London, England : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05478707 (Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes), which is not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 27506222PMID 23564922PMID 23052062PMID 22511259PMID 22362823PMID 22167126other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

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  8. Bioactivity and mechanisms of flavonoids in decreasing insulin resistance.Journal of enzyme inhibition and medicinal chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lina ZhaoDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, U.S.A.
Zhuo FuDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, U.S.A.
Jing WuDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, U.S.A. Department of Endocrinology, Central South University Xiangya Hospital, Changsha, Hunan 410008, China.
Kevin W AylorDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, U.S.A.
Eugene J BarrettDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, U.S.A.
Wenhong CaoDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27516, U.S.A.
Zhenqi LiuDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22903, U.S.A. zl3e@virginia.edu).
Xiangya Hospital Central South University · CN

Funding

Research Training in Neuroendocrinology and MetabolismT32DK007646 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZHENQI LIU · 1990 to 2026
$4.9M
GLP-1R Regulation of Insulin ActionR01DK102359 · NIDDK · UNIVERSITY OF VIRGINIA · PI LIU, ZHENQI · 2015 to 2019
$2.8M
Insulin action in human cardiac and skeletal muscle microvasculatureR01HL094722 · NHLBI · UNIVERSITY OF VIRGINIA · PI LIU, ZHENQI · 2010 to 2014
$1.9M
NHLBI NIH HHS R01HL094722NIDDK NIH HHS R01 DK102359NIDDK NIH HHS R01DK102359NIDDK NIH HHS T32-DK07646
6 · The paper itself

Abstract

Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the temporal relationship between vascular insulin resistance and metabolic insulin resistance. We assessed insulin responses in all arterial segments, including aorta, distal saphenous artery and the microvasculature, as well as the metabolic insulin responses in muscle in rats fed on a high-fat diet (HFD) for various durations ranging from 3 days to 4 weeks with or without sodium salicylate treatment. Compared with controls, HFD feeding significantly blunted insulin-mediated Akt (protein kinase B) and eNOS [endothelial nitric oxide (NO) synthase] phosphorylation in aorta in 1 week, blunted vasodilatory response in small resistance vessel in 4 weeks and microvascular recruitment in as early as 3 days. Insulin-stimulated whole body glucose disposal did not begin to progressively decrease until after 1 week. Salicylate treatment fully inhibited vascular inflammation, prevented microvascular insulin resistance and significantly improved muscle metabolic responses to insulin. We conclude that microvascular insulin resistance is an early event in diet-induced obesity and insulin resistance and inflammation plays an essential role in this process. Our data suggest microvascular insulin resistance contributes to the development of metabolic insulin resistance in muscle and muscle microvasculature is a potential therapeutic target in the prevention and treatment of diabetes and its related complications.

Indexed as

Diet, High-FatInsulin ResistanceMicrocirculationAnimalsAnti-Inflammatory Agents, Non-SteroidalBiomarkersBlood GlucoseDisease Models, AnimalInflammationInsulinMaleMicrovesselsMuscle, SkeletalNitric Oxide Synthase Type IIIObesityPhosphorylationAnti-Inflammatory Agents, Non-SteroidalBiomarkersBlood GlucoseInsulinNitric Oxide Synthase Type IIINos3 protein, ratProto-Oncogene Proteins c-aktSodium Salicylateendothelial dysfunctionhigh-fat dietinflammationinsulin resistancemuscle microvasculatureobesity

Identifiers

PMID26265791
PMCPMC4613534
OpenAlexW2201114134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.