ArticlePsychopharmacology2015
Diet-induced obesity and diet-resistant rats: differences in the rewarding and anorectic effects of D-amphetamine.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
- Reward sensitivity deficits in a rat model of compulsive eating behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neuropharmacology of compulsive eating.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats".Psychopharmacology · 2017Article
- Self-administered nicotine differentially impacts body weight gain in obesity-prone and obesity-resistant rats.Physiology & behavior · 2017Article
- Pathological Overeating: Emerging Evidence for a Compulsivity Construct.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Eating 'Junk-Food' Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Elevated Dopamine DNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Homeostasis Meets Motivation in the Battle to Control Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
- Strain and cocaine-induced differential opioid gene expression may predispose Lewis but not Fischer rats to escalate cocaine self-administration.Neuropharmacology · 2016Article
- Pre-existing differences and diet-induced alterations in striatal dopamine systems of obesity-prone rats.Obesity (Silver Spring, Md.) · 2016Article
- Enhanced cocaine-induced locomotor sensitization and intrinsic excitability of NAc medium spiny neurons in adult but not in adolescent rats susceptible to diet-induced obesity.Psychopharmacology · 2016Article
- Pre-existing differences in motivation for food and sensitivity to cocaine-induced locomotion in obesity-prone rats.Physiology & behavior · 2015Article
- Pituitary adenylate cyclase-activating polypeptide induces a depressive-like phenotype in rats.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
rationaleObesity is a leading public health problem worldwide. Multiple lines of evidence associate deficits in the brain reward circuit with obesity.
objectiveWhether alterations in brain reward sensitivity precede or are a consequence of obesity is unknown. This study aimed to investigate both innate and obesity-induced differences in the sensitivity to the effects of an indirect dopaminergic agonist.
methodsRats genetically prone to diet-induced obesity (DIO) and their counterpart diet-resistant (DR) were fed a chow diet, and their response to D-amphetamine on intracranial self-stimulation and food intake were assessed. The same variables were then evaluated after exposing the rats to a high-fat diet, after DIO rats selectively developed obesity. Finally, gene expression levels of dopamine receptors 1 and 2 as well as tyrosine hydroxylase were measured in reward-related brain regions.
resultsIn a pre-obesity state, DIO rats showed innate decreased sensitivity to the reward-enhancing and anorectic effects of D-amphetamine, as compared to DR rats. In a diet-induced obese state, the insensitivity to the potentiating effects of D-amphetamine on intracranial self-stimulation (ICSS) threshold persisted and became more marked in DIO rats, while the anorectic effects were comparable between genotypes. Finally, innate and obesity-induced differences in the gene expression of dopamine receptors were observed.
conclusionsOur results demonstrate that brain reward deficits antedate the development of obesity and worsen after obesity is fully developed, suggesting that these alterations represent vulnerability factors for its development. Moreover, our data suggests that the reward-enhancing and anorectic effects of D-amphetamine are dissociable in the context of obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.