← PCSK9 inhibitors × cardiovascular events

SynthesisAnnals of internal medicine2015

Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis.

Eliano Pio Navarese et al.PubMed ↗Publisher ↗

What the trial testedas reported · 159 people · 2015

Not counted

Probably reduced cardiovascular events

−51%−74% to −7%

Bigger than 9 in 10 for cardiovascular events

As reported

OR 0.49, 95% CI 0.26–0.93

Not counted

Probably reduced cardiovascular events

−47.5percentage points−69.6 to −25.4

As reported

difference −47.49 %, 95% CI −69.6 to −25.4

Not counted

Probably reduced cardiovascular events

−28%−46% to −4%

Bigger than 7 in 10 for cardiovascular events

As reported

OR 0.72, 95% CI 0.54–0.96

Not counted

Probably reduced cardiovascular events

−55%−77% to −14%

Bigger than 9 in 10 for cardiovascular events

As reported

OR 0.45, 95% CI 0.23–0.86

+1 more in the walkthrough ↓

Five numbers in the abstract

the abstract, start to end

… with use of PCSK9 antibodies (OR, 0.49 [CI, 0.26 to 0.93]; P = 0.030; heterogeneity P = 0.45; I2 = 0%), and increases in the serum creatine kinase level were reduced (OR, 0.72 [CI, 0.54 to 0.96]; P = 0.026; …

… cholesterol levels (mean difference, -47.49% [95% CI, -69.64% to -25.35%]; P < 0.001] and other atherogenic lipid fractions, and it reduced all-cause mortality (odds ratio [OR], 0.45 [CI, 0.23 to 0.86]; P = 0.015; heterogeneity P = 0.63; I2 = 0%) and cardiovascular mortality (OR, 0.50 [CI, 0.23 to 1.10]; P = 0.084; …

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
OR 0.490.26–0.93
Cardiovascular events
−47.49−69.6 to −25.4
Cardiovascular events
OR 0.720.54–0.96
Cardiovascular events
OR 0.450.23–0.86
Cardiovascular events
OR 0.500.23–1.10
PCSK9 inhibitorsCardiovascular events
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Full record →Abstract, authors, funding and every citing paper · PMID 25915661