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SynthesisBMC medicine2017

Comparison of the effects of fibrates versus statins on plasma lipoprotein(a) concentrations: a systematic review and meta-analysis of head-to-head randomized controlled trials.

Amirhossein Sahebkar et al.PubMed ↗Full text ↗Publisher ↗

  • Fibrateslooks good hereLower reducing plasma Lp concentrations.Randomised, large.
  • Fibrates and statins (combination therapy)no clear effectLower reducing plasma Lp concentrations, no clear effect on reducing plasma Lp concentrations.Nothing cleared the noise.

What the trial testedrandomised · 1,388 people · 2017

Randomised vs statins

Lowered reducing plasma Lp concentrations

−2.70mg/dL−4.56 to −0.84

fibrates vs statins

As reported

difference −2.70 mg/dL, 95% CI −4.56 to −0.84

Not counted

Lowered reducing plasma Lp concentrations

−1.60mg/dL−2.93 to −0.26

fibrates and statins (combination therapy) vs statin monotherapy

As reported

difference −1.60 mg/dL, 95% CI −2.93 to −0.26

Range includes no effect

No clear effect on reducing plasma Lp concentrations

−1.76mg/dL−5.44 to +1.92

fibrates and statins (combination therapy) vs fibrate monotherapy

As reported

difference −1.76 mg/dL, 95% CI −5.44 to 1.92

Who was studied, and how

1,388people with cardiovascular disease, in this paper

The trial randomly assignedassigned by chance

fibrates and statins (combination therapy)
statin monotherapy

Lowered reducing plasma Lp concentrations−1.60

randomised

The trial randomly assignedassigned by chance

fibrates
statins

Lowered reducing plasma Lp concentrations−2.70

randomised

the abstract, start to end

… compared with statin monotherapy (WMD, -1.60 mg/dL; 95% CI, -2.93 to -0.26; P = 0.019) but not fibrate monotherapy (WMD, -1.76 mg/dL; 95% CI, -5.44 to +1.92; …

… plasma Lp(a) concentrations (WMD, -2.70 mg/dL; 95% CI, -4.56 to -0.84; …

← favours treatmentfavours comparator →
could be chance
Reducing plasma Lp(a) concentrationsfibrates and statins (combination therapy) vs statin monotherapy
−1.60−2.93 to −0.26
Reducing plasma Lp(a) concentrationsfibrates vs statins
−2.70−4.56 to −0.84
Reducing plasma Lp(a) concentrationsfibrates and statins (combination therapy) vs fibrate monotherapy
−1.76−5.44 to 1.92
StatinsOther lipid agentsLipids
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Full record →Abstract, authors, funding and every citing paper · PMID 28153024