Evidence map›Paper›PMID 25463973›Full record

ArticleTranslational psychiatry2014

A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly.

T Shah, G Verdile, H Sohrabi, A Campbell, E Putland, C Cheetham, S Dhaliwal, M Weinborn, P Maruff, D Darby and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  10. A multidomain trial for cognition in women with cardiovascular disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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  15. Changes in Moderate Intensity Physical Activity Are Associated With Better Cognition in the Multilevel Intervention for Physical Activity in Retirement Communities (MIPARC) Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

T Shah1] School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia [2] The McCusker Alzheimer's Research Foundation (Hollywood Private Hospital), Hollywood Medical Centre, Perth, WA, Australia [3] Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, WA, Australia.
G Verdile1] The McCusker Alzheimer's Research Foundation (Hollywood Private Hospital), Hollywood Medical Centre, Perth, WA, Australia [2] Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, WA, Australia [3] School of Biomedical Sciences, Curtin University, Perth, WA, Australia.
H Sohrabi1] School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia [2] The McCusker Alzheimer's Research Foundation (Hollywood Private Hospital), Hollywood Medical Centre, Perth, WA, Australia [3] Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, WA, Australia.
A CampbellDepartment of Nuclear Medicine, Royal Perth Hospital, Perth, WA, Australia.
E PutlandThe McCusker Alzheimer's Research Foundation (Hollywood Private Hospital), Hollywood Medical Centre, Perth, WA, Australia.
C Cheetham1] Health Care Western Australia, Hollywood Private Hospital, Perth, WA, Australia [2] School of Sports Science, Exercise and Health, University of Western Australia, Perth, WA, Australia.
S DhaliwalSchool of Public Health, Curtin University, Perth, WA, Australia.
M Weinborn1] The McCusker Alzheimer's Research Foundation (Hollywood Private Hospital), Hollywood Medical Centre, Perth, WA, Australia [2] School of Psychology, University of Western Australia, Perth, WA, Australia.
P Maruff1] Mental Health Research Institute, The University of Melbourne, Parkville, VIC, Australia [2] CogState Ltd, Melbourne, VIC, Australia.
D Darby1] Mental Health Research Institute, The University of Melbourne, Parkville, VIC, Australia [2] CogState Ltd, Melbourne, VIC, Australia [3] Florey Neuroscience Institutes, Carlton South, VIC, Australia.
R N Martins1] School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, WA, Australia [2] The McCusker Alzheimer's Research Foundation (Hollywood Private Hospital), Hollywood Medical Centre, Perth, WA, Australia [3] Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, WA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical exercise interventions and cognitive training programs have individually been reported to improve cognition in the healthy elderly population; however, the clinical significance of using a combined approach is currently lacking. This study evaluated whether physical activity (PA), computerized cognitive training and/or a combination of both could improve cognition. In this nonrandomized study, 224 healthy community-dwelling older adults (60-85 years) were assigned to 16 weeks home-based PA (n=64), computerized cognitive stimulation (n=62), a combination of both (combined, n=51) or a control group (n=47). Cognition was assessed using the Rey Auditory Verbal Learning Test, Controlled Oral Word Association Test and the CogState computerized battery at baseline, 8 and 16 weeks post intervention. Physical fitness assessments were performed at all time points. A subset (total n=45) of participants underwent [(18)F] fluorodeoxyglucose positron emission tomography scans at 16 weeks (post-intervention). One hundred and ninety-one participants completed the study and the data of 172 participants were included in the final analysis. Compared with the control group, the combined group showed improved verbal episodic memory and significantly higher brain glucose metabolism in the left sensorimotor cortex after controlling for age, sex, premorbid IQ, apolipoprotein E (APOE) status and history of head injury. The higher cerebral glucose metabolism in this brain region was positively associated with improved verbal memory seen in the combined group only. Our study provides evidence that a specific combination of physical and mental exercises for 16 weeks can improve cognition and increase cerebral glucose metabolism in cognitively intact healthy older adults.

Indexed as

Memory, EpisodicAgedAged, 80 and overAgingCombined Modality TherapyFluorodeoxyglucose F18GlucoseHumansMaleMiddle AgedMotor ActivityPositron-Emission TomographyRadiopharmaceuticalsSensorimotor CortexTherapy, Computer-AssistedTreatment OutcomeFluorodeoxyglucose F18GlucoseRadiopharmaceuticals

Identifiers

PMID25463973
PMCPMC4270308

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.