Evidence map›Paper›PMID 25332332›Full record

ArticleThe American journal of clinical nutrition2014

Intake of dietary flavonoids and risk of epithelial ovarian cancer.

Aedín Cassidy, Tianyi Huang, Megan S Rice, Eric B Rimm, Shelley S Tworoger

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Quercetin: A Natural Ally in Combating Breast Cancer.International journal of nanomedicine · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Prevention of Epithelial Ovarian Cancer.Cold Spring Harbor perspectives in medicine · 2023
    Review
  11. Beneficial Role of Vitexin in Parkinson's Disease.The Malaysian journal of medical sciences : MJMS · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Therapeutic Potential of Isoflavones with an Emphasis on Daidzein.Oxidative medicine and cellular longevity · 2021
    Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aedín CassidyFrom the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (AC); the Department of Epidemiology, Harvard School of Public Health, Boston, MA (TH, MSR, EBR, and SST); and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (TH, MSR, EBR, and SST).
Tianyi HuangFrom the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (AC); the Department of Epidemiology, Harvard School of Public Health, Boston, MA (TH, MSR, EBR, and SST); and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (TH, MSR, EBR, and SST).
Megan S RiceFrom the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (AC); the Department of Epidemiology, Harvard School of Public Health, Boston, MA (TH, MSR, EBR, and SST); and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (TH, MSR, EBR, and SST).
Eric B RimmFrom the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (AC); the Department of Epidemiology, Harvard School of Public Health, Boston, MA (TH, MSR, EBR, and SST); and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (TH, MSR, EBR, and SST).
Shelley S TworogerFrom the Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom (AC); the Department of Epidemiology, Harvard School of Public Health, Boston, MA (TH, MSR, EBR, and SST); and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (TH, MSR, EBR, and SST).
Brigham and Women's Hospital · US

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Biotechnology and Biological Sciences Research Council BB/J004545/1NCI NIH HHS P01 CA 87969NCI NIH HHS T32CA 09001NCI NIH HHS UM1 CA 176726
6 · The paper itself

Abstract

backgroundThe impact of different dietary flavonoid subclasses on risk of epithelial ovarian cancer is unclear, with limited previous studies that have focused on only a few compounds.

objectiveWe prospectively examined associations between habitual flavonoid subclass intake and risk of ovarian cancer.

designWe followed 171,940 Nurses' Health Study and Nurses' Health Study II participants to examine associations between intakes of total flavonoids and their subclasses (flavanones, flavonols, anthocyanins, flavan-3-ols, flavones, and polymeric flavonoids) and risk of ovarian cancer by using Cox proportional hazards models. Intake was calculated from validated food-frequency questionnaires collected every 4 y.

resultsDuring 16-22 y of follow-up, 723 cases of ovarian cancer were confirmed through medical records. In pooled multivariate-adjusted analyses, total flavonoids were not statistically significantly associated with ovarian cancer risk (HR for the top compared with the bottom quintile: 0.85; 95% CI: 0.66, 1.09; P-trend = 0.17). However, participants in the highest quintiles of flavonol and flavanone intakes had modestly lower risk of ovarian cancer than did participants in the lowest quintile, although the P-trend was not significant [HRs: 0.76 (95% CI: 0.59, 0.98; P-trend = 0.11) and 0.79 (95% CI: 0.63,1.00; P-trend = 0.26), respectively]. The association for flavanone intake was stronger for serous invasive and poorly differentiated tumors (comparable HR: 0.68; 95% CI: 0.50, 0.92; P-heterogeneity = 0.10, P-trend = 0.07) compared with nonserous and less-aggressive tumors. Intakes of other subclasses were not significantly associated with risk. In food-based analyses used to compare subjects who consumed >1 and ≤ 1 cup black tea/d, the HR was 0.68 (95% CI: 0.51, 0.90; P < 0.01).

conclusionsHigher intakes of flavonols and flavanones as well as black tea consumption may be associated with lower risk of ovarian cancer. Additional prospective studies are required to confirm these findings.

Indexed as

AdultAnthocyaninsCarcinoma, Ovarian EpithelialFemaleFlavanonesFlavonesFlavonoidsFlavonolsFollow-Up StudiesHumansMiddle AgedMultivariate AnalysisNeoplasms, Glandular and EpithelialOvarian NeoplasmsProportional Hazards ModelsProspective StudiesAnthocyaninsflavan-3-olFlavanonesflavoneFlavonesFlavonoidsFlavonolsTea

Identifiers

PMID25332332
PMCPMC4196485
OpenAlexW2121005650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.