ArticleJournal of proteome research2015
Specific nongluten proteins of wheat are novel target antigens in celiac disease humoral response.
Article in Journal of proteome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Celiac disease serology and gut microbiome following proton pump inhibitor treatment.Medicine · 2020Trial
- Heterologous Expression and Immunoreactivity of Wheat Amylase-Trypsin Inhibitors.International journal of molecular sciences · 2026Article
- Psychiatric Symptoms Associated with Non-Celiac Gluten Sensitivity: A Focused Narrative Review.Nutrients · 2026Review
- Gastrointestinal symptoms correlate with core clinical features and systemic inflammation in myalgic encephalomyelitis/chronic fatigue syndrome.Journal of translational medicine · 2026Article
- Plant Serpins: Potential Inhibitors of Serine and Cysteine Proteases with Multiple Functions.Plants (Basel, Switzerland) · 2023Review
- Suppressed immune and metabolic responses to intestinal damage-associated microbial translocation in myalgic encephalomyelitis/chronic fatigue syndrome.Brain, behavior, & immunity - health · 2023Article
- Does sourdough bread provide clinically relevant health benefits?Frontiers in nutrition · 2023Review
- Impact of food processing on the allergenic properties of amylase trypsin inhibitors from wheat.Frontiers in allergy · 2023Review
- Do ancient wheats contain less gluten than modern bread wheat, in favour of better health?Nutrition bulletin · 2022Review
- Absolute and relative quantitation of amylase/trypsin-inhibitors by LC-MS/MS from wheat lines obtained by CRISPR-Cas9 and RNAi.Frontiers in plant science · 2022Article
- Contribution of Infectious Agents to the Development of Celiac Disease.Microorganisms · 2021Review
- Wheat ATIs: Characteristics and Role in Human Disease.Frontiers in nutrition · 2021Review
- Insights into the Potential of Sourdough-Related Lactic Acid Bacteria to Degrade Proteins in Wheat.Microorganisms · 2020Article
- Wheat-induced food allergy in childhood: ancient grains seem no way out.European journal of nutrition · 2020Article
- Comprehensive Comparison of Clinically Relevant Grain Proteins in Modern and Traditional Bread Wheat Cultivars.International journal of molecular sciences · 2020Article
- Deciphering the immunogenic potential of wheat flour: a reference map of the salt-soluble proteome from the U.S. wheat Butte 86.Proteome science · 2020Article
- The Two Faces of Wheat.Frontiers in nutrition · 2020Review
- Stimulatory Response of Celiac Disease Peripheral Blood Mononuclear Cells Induced by RNAi Wheat Lines Differing in Grain Protein Composition.Nutrients · 2019Article
- Article
- Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.Nature communications · 2019Article
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Authors and funding
11 authors.
Funding
Abstract
While the antigenic specificity and pathogenic relevance of immunologic reactivity to gluten in celiac disease have been extensively researched, the immune response to nongluten proteins of wheat has not been characterized. We aimed to investigate the level and molecular specificity of antibody response to wheat nongluten proteins in celiac disease. Serum samples from patients and controls were screened for IgG and IgA antibody reactivity to a nongluten protein extract from the wheat cultivar Triticum aestivum Butte 86. Antibodies were further analyzed for reactivity to specific nongluten proteins by two-dimensional gel electrophoresis and immunoblotting. Immunoreactive molecules were identified by tandem mass spectrometry. Compared with healthy controls, patients exhibited significantly higher levels of antibody reactivity to nongluten proteins. The main immunoreactive nongluten antibody target proteins were identified as serpins, purinins, α-amylase/protease inhibitors, globulins, and farinins. Assessment of reactivity toward purified recombinant proteins further confirmed the presence of antibody response to specific antigens. The results demonstrate that, in addition to the well-recognized immune reaction to gluten, celiac disease is associated with a robust humoral response directed at a specific subset of the nongluten proteins of wheat.
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