ArticleJournal of industrial microbiology & biotechnology2014
High vanillin tolerance of an evolved Saccharomyces cerevisiae strain owing to its enhanced vanillin reduction and antioxidative capacity.
Article in Journal of industrial microbiology & biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Highly Efficient Production of Cellulosic Ethanol from Poplar Using an Optimal C6/C5 Co-Fermentation Strain ofMicroorganisms · 2024Article
- Xylose consumption and ethanol production by Pichia guilliermondii and Candida oleophila in the presence of furans, phenolic compounds, and organic acids commonly produced during the pre-treatment of plant biomass.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- How adaptive laboratory evolution can boost yeast tolerance to lignocellulosic hydrolyses.Current genetics · 2022Review
- Low-Temperature Biodegradation of Lignin-Derived Aromatic Model Monomers by the Cold-Adapted YeastMicroorganisms · 2022Article
- Biosynthesis of vanillin by different microorganisms: a review.World journal of microbiology & biotechnology · 2022Review
- Capture Hi-C reveals the influence on dynamic three-dimensional chromosome organization perturbed by genetic variation or vanillin stress inFrontiers in microbiology · 2022Article
- A novel AST2 mutation generated upon whole-genome transformation of Saccharomyces cerevisiae confers high tolerance to 5-Hydroxymethylfurfural (HMF) and other inhibitors.PLoS genetics · 2021Article
- Proteomic analysis revealed the roles of YRR1 deletion in enhancing the vanillin resistance of Saccharomyces cerevisiae.Microbial cell factories · 2021Article
- Variable and dose-dependent response of Saccharomyces and non-Saccharomyces yeasts toward lignocellulosic hydrolysate inhibitors.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Identification of the major fermentation inhibitors of recombinant 2G yeasts in diverse lignocellulose hydrolysates.Biotechnology for biofuels · 2021Article
- Newly identified genes contribute to vanillin tolerance in Saccharomyces cerevisiae.Microbial biotechnology · 2021Article
- A CRISPR activation and interference toolkit for industrial Saccharomyces cerevisiae strain KE6-12.Scientific reports · 2020Article
- Multi-Faceted Systems Biology Approaches Present a Cellular Landscape of Phenolic Compound Inhibition inFrontiers in bioengineering and biotechnology · 2020Review
- Gene coexpression network analysis reveals a novel metabolic mechanism ofBiotechnology for biofuels · 2020Article
- Bacterial conversion of depolymerized Kraft lignin.Biotechnology for biofuels · 2019Article
- Bacterial conversion of depolymerized Kraft lignin.Biotechnology for biofuels · 2018Article
- Vanillin Promotes the Germination ofFrontiers in microbiology · 2017Article
- Increased lignocellulosic inhibitor tolerance ofBiotechnology for biofuels · 2017Article
- The Absence of the Transcription Factor Yrr1p, Identified from Comparative Genome Profiling, Increased Vanillin Tolerance Due to Enhancements of ABC Transporters Expressing, rRNA Processing and Ribosome Biogenesis inFrontiers in microbiology · 2017Article
- Identification and functional evaluation of the reductases and dehydrogenases from Saccharomyces cerevisiae involved in vanillin resistance.BMC biotechnology · 2016Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenolic compounds present in hydrolysates pose significant challenges for the sustainable lignocellulosic materials refining industry. Three Saccharomyces cerevisiae strains with high tolerance to lignocellulose hydrolysate were obtained through ethyl methanesulfonate mutation and adaptive evolution. Among them, strain EMV-8 exhibits specific tolerance to vanillin, a phenolic compound common in lignocellulose hydrolysate. The EMV-8 maintains a specific growth rate of 0.104 h(-1) in 2 g L(-1) vanillin, whereas the reference strain cannot grow. Physiological studies revealed that the vanillin reduction rate of EMV-8 is 1.92-fold higher than its parent strain, and the Trolox equivalent antioxidant capacity of EMV-8 is 15 % higher than its parent strain. Transcriptional analysis results confirmed an up-regulated oxidoreductase activity and antioxidant activity in this strain. Our results suggest that enhancing the antioxidant capacity and oxidoreductase activity could be a strategy to engineer S. cerevisiae for improved vanillin tolerance.
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