ArticleIranian journal of medical sciences2014
Effects of pomegranate seed oil on insulin release in rats with type 2 diabetes.
Article in Iranian journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Punicic Acid: A Potential Nutraceutical Compound in Pomegranate Seed Oil and Its Cardiovascular Benefits.Foods (Basel, Switzerland) · 2025Article
- An Overview of the Health Benefits, Extraction Methods and Improving the Properties of Pomegranate.Antioxidants (Basel, Switzerland) · 2023Review
- Pomegranate Seed Oil as a Source of Conjugated Linolenic Acid (CLnA) Has No Effect on Atherosclerosis Development but Improves Lipid Profile and Affects the Expression of Lipid Metabolism Genes in apoE/LDLRInternational journal of molecular sciences · 2023Article
- Improved biological value of eggs due to the addition of pomegranate seed oil to laying-hen diets.Archives animal breeding · 2023Article
- Cold-Pressed Pomegranate Seed Oil: Study of Punicic Acid Properties by Coupling of GC/FID and FTIR.Molecules (Basel, Switzerland) · 2022Article
- Fatty acids compositional variations between the edible and non-edible fruit part of seven pomegranate varieties.Food chemistry. Molecular sciences · 2021Article
- The Egg Yolk Content in ω-3 and Conjugated Fatty Acids Can Be Sustainably Increased upon Long-Term Feeding of Laying Hens with a Diet Containing Flaxseeds and Pomegranate Seed Oil.Foods (Basel, Switzerland) · 2021Article
- Nutritional and Bioactive Components of Pomegranate Waste Used in Food and Cosmetic Applications: A Review.Foods (Basel, Switzerland) · 2021Review
- Pomegranate variety and pomegranate plant part, relevance from bioactive point of view: a review.Bioresources and bioprocessing · 2021Review
- Bioactive Compounds and Pharmacological Potential of Pomegranate (Punica granatum) Seeds - A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Review
- Punicic acid: A striking health substance to combat metabolic syndromes in humans.Lipids in health and disease · 2017Review
- The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats.BMC complementary and alternative medicine · 2017Article
- Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats.International journal of ophthalmology · 2017Article
- Pomegranate juice causes a partial improvement through lowering oxidative stress for erectile dysfunction in streptozotocin-diabetic rat.International journal of impotence research · 2016Article
- Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects.Iranian journal of medical sciences · 2016Article
- Effects of Pomegranate Seed Oil on Metabolic State of Patients with Type 2 Diabetes Mellitus.International journal of preventive medicine · 2016Article
- The effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms.Iranian journal of medical sciences · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPomegranate seed oil and its main constituent, punicic acid, have been shown to decrease plasma glucose and have antioxidant activity. The objective of the present study was to examine the effects of pomegranate seed oil on rats with type 2 diabetes mellitus.
methodSix groups (n=8 each) of male Sprague-Dawley rats, comprising a control, a diabetic (induced by Streptozocin and Nicotinamide) receiving water as vehicle, a diabetic receiving pomegranate seed oil (200 mg/kg/day), a diabetic receiving pomegranate seed oil (600 mg/kg/day), a diabetic receiving soybean oil (200 mg/kg/day), and a diabetic receiving soybean oil (600 mg/kg/day), were used. After 28 days of receiving vehicle or oils, blood glucose, serum levels of insulin, malondialdehyde, glutathione peroxidase, and lipid profile were determined.
resultsThe diabetic rats had significantly higher levels of blood glucose, serum triglyceride, low-density lipoprotein cholesterol, total cholesterol, and malondialdehyde and lower levels of serum insulin and glutathione peroxidase. Rats treated with pomegranate seed oil had significantly higher levels of serum insulin and glutathione peroxidase activity, and there were no statistically significant differences in terms of blood glucose between them and the diabetic control group.
conclusionThe findings of the present study suggest that pomegranate seed oil improved insulin secretion without changing fasting blood glucose.
Indexed as
Identifiers
24644382PMC3957012W1569507777What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.