Evidence map›Paper›PMID 24516645›Full record

Trial reportPloS one2014

Effect of 24 sessions of high-intensity aerobic interval training carried out at either high or moderate frequency, a randomized trial.

Håvard Hatle, Per Kristian Støbakk, Harald Edvard Mølmen, Eivind Brønstad, Arnt Erik Tjønna, Sigurd Steinshamn, Eirik Skogvoll, Ulrik Wisløff, Charlotte Björk Ingul, Øivind Rognmo

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00733941 (Interval Training), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00733941 nacompletednot on this map

Interval Training: Training, Detraining and Retraining; an Interventional Study

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2008 to 2009Enrolled24ConditionsHealthy Subjects, Exercise TestArmsHigh frequency training, normal frequence training
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
    Pooled it
  2. Trial
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  8. Why low-intensity endurance training for athletes?European journal of applied physiology · 2025
    Review
  9. Article
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  11. VOHeliyon · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Håvard HatleK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Per Kristian StøbakkK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Harald Edvard MølmenK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Eivind BrønstadK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway ; Department of Pulmonary Medicine, St Olav University Hospital, Trondheim, Norway.
Arnt Erik TjønnaK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Sigurd SteinshamnK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway ; Department of Pulmonary Medicine, St Olav University Hospital, Trondheim, Norway.
Eirik SkogvollDepartment of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Ulrik WisløffK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Charlotte Björk IngulK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.
Øivind RognmoK.G. Jebsen Centre of Exercise in Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway ; Department of Circulation and Medical Imaging, NTNU, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe training response of an intensified period of high-intensity exercise is not clear. Therefore, we compared the cardiovascular adaptations of completing 24 high-intensity aerobic interval training sessions carried out for either three or eight weeks, respectively.

methodsTwenty-one healthy subjects (23.0±2.1 years, 10 females) completed 24 high-intensity training sessions throughout a time-period of either eight weeks (moderate frequency, MF) or three weeks (high frequency, HF) followed by a detraining period of nine weeks without any training. In both groups, maximal oxygen uptake (VO2max) was evaluated before training, at the 9(th) and 17(th) session and four days after the final 24(th) training session. In the detraining phase VO2max was evaluated after 12 days and thereafter every second week for eight weeks. Left ventricular echocardiography, carbon monoxide lung diffusion transfer factor, brachial artery flow mediated dilatation and vastus lateralis citrate maximal synthase activity was tested before and after training.

resultsThe cardiovascular adaptation after HF training was delayed compared to training with MF. Four days after ending training the HF group showed no improvement (+3.0%, p = 0.126), whereas the MF group reached their highest VO2max with a 10.7% improvement (p<0.001: group difference p = 0.035). The HF group reached their highest VO2max (6.1% increase, p = 0.026) twelve days into the detraining period, compared to a concomitant reduction to 7.9% of VO2max (p<0.001) above baseline in the MF group (group difference p = 0.609).

conclusionBoth HF and MF training of high-intensity aerobic exercise improves VO2max. The cardiovascular adaptation following a HF programme of high-intensity exercise is however delayed compared to MF training.

trial registrationClinicalTrials.gov NCT00733941.

Indexed as

Adaptation, PhysiologicalAdultBrachial ArteryEchocardiographyExerciseFemaleHumansMaleMuscle, SkeletalOxygen ConsumptionRespiratory Function TestsStroke VolumeTreatment OutcomeVentricular FunctionYoung Adult

Identifiers

PMID24516645
PMCPMC3917911

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.