Evidence map›Paper›PMID 24489845›Full record

ArticlePloS one2014

Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study.

Chin-Chou Huang, Chia-Min Chung, Hsin-Bang Leu, Liang-Yu Lin, Chun-Chih Chiu, Chien-Yi Hsu, Chia-Hung Chiang, Po-Hsun Huang, Tzeng-Ji Chen, Shing-Jong Lin and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 9 pooled it
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 9 syntheses or guidelines pooled it, 261 citations in OpenAlex.

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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Chin-Chou HuangDepartment of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Chia-Min ChungEnvironment-Omics-Disease Research Centre, China Medical University Hospital, Taichung, Taiwan, R.O.C ; Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan, R.O.C.
Hsin-Bang LeuDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Liang-Yu LinDivision of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Chun-Chih ChiuDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Chien-Yi HsuDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Chia-Hung ChiangCardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Division of Cardiology, Department of Medicine, Zhudong Veterans Hospital, HsinChu, Taiwan, R.O.C.
Po-Hsun HuangDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Tzeng-Ji ChenDepartment of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Shing-Jong LinDepartment of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Jaw-Wen ChenDepartment of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, R.O.C ; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan, R.O.C.
Wan-Leong ChanDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Healthcare and Management Center, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C ; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, R.O.C.
National Yang Ming Chiao Tung University · TWTaipei Veterans General Hospital · TWChina Medical University Hospital · TWNational Yang Ming University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPossible association between diabetes mellitus (DM) and Alzheimer's disease (AD) has been controversial. This study used a nationwide population-based dataset to investigate the relationship between DM and subsequent AD incidence.

methodsData were collected from Taiwan's National Health Insurance Research Database, which released a cohort dataset of 1,000,000 randomly sampled people and confirmed it to be representative of the Taiwanese population. We identified 71,433 patients newly diagnosed with diabetes (age 58.74 ± 14.02 years) since January 1997. Using propensity score, we matched them with 71,311 non-diabetic subjects by time of enrollment, age, gender, hypertension, hyperlipidemia, and previous stroke history. All the patients were followed up to December 31, 2007. The endpoint of the study was occurrence of AD.

resultsOver a maximum 11 years of follow-up, diabetic patients experienced a higher incidence of AD than non-diabetic subjects (0.48% vs. 0.37%, p<0.001). After Cox proportional hazard regression model analysis, DM (hazard ratio [HR], 1.76; 95% confidence interval [CI], 1.50-2.07, p<0.001), age (HR, 1.11; 95% CI, 1.10-1.12, p<0.001), female gender (HR, 1.24; 95% CI, 1.06-1.46, p=0.008), hypertension (HR, 1.30; 95% CI, 1.07-1.59, p=0.01), previous stroke history (HR, 1.79; 95% CI, 1.28-2.50, p<0.001), and urbanization status (metropolis, HR, 1.32; 95% CI, 1.07-1.63, p=0.009) were independently associated with the increased risk of AD. Neither monotherapy nor combination therapy with oral antidiabetic medications were associated with the risk of AD after adjusting for underlying risk factors and the duration of DM since diagnosis. However, combination therapy with insulin was found to be associated with greater risk of AD (HR, 2.17; 95% CI, 1.04-4.52, p=0.039).

conclusionNewly diagnosed DM was associated with increased risk of AD. Use of hypoglycemic agents did not ameliorate the risk.

Indexed as

AgedAlzheimer DiseaseCase-Control StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedProportional Hazards Models

Identifiers

PMID24489845
PMCPMC3906115
OpenAlexW2096970718

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.