ArticlePreventive nutrition and food science2013
Anticoagulant and Antiplatelet Activities of Artemisia princeps Pampanini and Its Bioactive Components.
Article in Preventive nutrition and food science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- The combination of Korean Sajabal mugwort (Food science and biotechnology · 2025Article
- The Antiviral and Antimalarial Prodrug Artemisinin from theCurrent issues in molecular biology · 2024Review
- The synergistic effects of Korean Red Ginseng andJournal of ginseng research · 2024Article
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- Natural Phenolic Compounds with Antithrombotic and Antiplatelet Effects: A Drug-likeness Approach.Current medicinal chemistry · 2024Review
- Reversible and Non-Competitive Inhibition of Cyclooxygenase by Indobufen for Efficient Antiplatelet Action and Relief of Gastrointestinal Irritation.Pharmaceutics · 2023Article
- Pretreatment with Eupatilin Attenuates Inflammation and Coagulation in Sepsis by Suppressing JAK2/STAT3 Signaling Pathway.Journal of inflammation research · 2023Article
- Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods.Molecules (Basel, Switzerland) · 2022Review
- Review
- Article
- Anticoagulant Activities of Indobufen, an Antiplatelet Drug.Molecules (Basel, Switzerland) · 2018Article
- Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation.PloS one · 2017Article
- Fermented rice bran prevents atopic dermatitis in DNCB-treated NC/Nga mice.Journal of biomedical research · 2016Article
- Effects of Artemisia Princeps Supplementation on Bone Metabolism in Ovariectomized Rats.The journal of nutrition, health & aging · 2016Article
- Anti-Inflammatory Effects of Artemisia Leaf Extract in Mice with Contact Dermatitis In Vitro and In Vivo.Mediators of inflammation · 2016Article
- Characterization of Nutritional Composition, Antioxidative Capacity, and Sensory Attributes of Seomae Mugwort, a Native Korean Variety of Artemisia argyi H. Lév. & Vaniot.Journal of analytical methods in chemistry · 2015Article
- Natural Products for Antithrombosis.Evidence-based complementary and alternative medicine : eCAM · 2015Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisia princeps Pampanini (AP) has been used as a traditional medicine in Korea, China and Japan and reported to exhibit various beneficial biological effects including anti-inflammatory, antioxidant, anti-atherogenic and lipid lowering activities; however, its antiplatelet and anticoagulant properties have not been studied. In the present study, we evaluated the effects of an ethanol extract of Artemisia princeps Pampanini (EAP) and its major flavonoids, eupatilin and jaceosidin, on platelet aggregation and coagulation. To determine the antiplatelet activity, arachidonic acid (AA)-, collagen- and ADP (adenosine diphosphate)-induced platelet aggregation were examined along with serotonin and thromboxane A2 (TXA2) generation in vitro. The anticoagulant activity was determined by monitoring the activated partial thromboplastin time (aPTT) and prothrombin time (PT) in vitro. The data showed that EAP and its major flavonoids, eupatilin and jaceosidin, significantly reduced AA-induced platelet aggregation and the generation of serotonin and TXA2, although no significant change in platelet aggregation induced by collagen and ADP was observed. Moreover, EAP significantly prolonged the PT and aPTT. The PT and/or aPTT were significantly increased in the presence of eupatilin and jaceosidin. Thus, these results suggest that EAP may have the potential to prevent or improve thrombosis by inhibiting platelet activation and blood coagulation.
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