Evidence map›Paper›PMID 24456663›Full record

Trial reportProstaglandins, leukotrienes, and essential fatty acids2014

A low omega-6 polyunsaturated fatty acid (n-6 PUFA) diet increases omega-3 (n-3) long chain PUFA status in plasma phospholipids in humans.

K E Wood, A Lau, E Mantzioris, R A Gibson, C E Ramsden, B S Muhlhausler

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Prostaglandins, leukotrienes, and essential fatty acids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  4. Review
  5. Article
  6. Review
  7. Article
  8. Anti-inflammatory effect ofResearch in pharmaceutical sciences · 2021
    Article
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  20. Public Health Perspectives on Aquaculture.Current environmental health reports · 2014
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

K E WoodSchool of Medicine, Department of Nutrition and Dietetics, Flinders University, Adelaide, SA 5042, Australia; FOODplus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5064, Australia.
A LauSchool of Medicine, Department of Nutrition and Dietetics, Flinders University, Adelaide, SA 5042, Australia.
E MantziorisSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia.
R A GibsonFOODplus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5064, Australia.
C E RamsdenLaboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
B S MuhlhauslerFOODplus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, SA 5064, Australia. Electronic address: beverly.muhlhausler@adelaide.edu.au.
Flinders University · AUNational Institute on Alcohol Abuse and Alcoholism · USUniversity of Adelaide · AUUniversity of South Australia · AU

Funding

Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

This study aimed to determine the effect of reducing the dietary linoleic acid (LA) intake from ~5% to <2.5% energy (%E) on n-3 long chain PUFA (LCPUFA) status in humans. Thirty-six participants followed a <2.5%E LA diet for 4 weeks. Nutrient intakes were estimated from diet diaries and blood samples were collected for assessment of fatty acid composition in plasma and erythrocyte phospholipids. LA intakes were reduced from 4.6%E to 2%E during the low LA intervention (P<0.001) while n-3 LCPUFA intakes were unchanged. LA and total n-6 PUFA content of plasma and erythrocyte phospholipids were significantly reduced after the low LA diet phase (P<0.001). The n-3 LCPUFA content of plasma phospholipids was significantly increased after the low LA diet compared to baseline (6.22% vs. 5.53%, P<0.001). These data demonstrate that reducing LA intake for 4 weeks increases n-3 LCPUFA status in humans in the absence of increased n-3 LCPUFA intake.

Indexed as

AdultDietErythrocytesFatty Acids, Omega-3FemaleHumansLinoleic AcidMaleMiddle AgedPhospholipidsYoung AdultFatty Acids, Omega-3Linoleic AcidPhospholipidsALADietLinoleic acid (LA)Omega-3 PUFAOmega-6 PUFA

Identifiers

PMID24456663
PMCPMC9398218
OpenAlexW2010184926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.