ArticlePloS one2014
Olives and olive oil are sources of electrophilic fatty acid nitroalkenes.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 114 citations in OpenAlex.
- Nitro-fatty acids-mediated nitroalkylation modulates fine-tuning catalase antioxidant function during salinity stress in plants.Protein science : a publication of the Protein Society · 2025Article
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.Chemical reviews · 2025Review
- The chemical biology of dinitrogen trioxide.Redox biochemistry and chemistry · 2024Article
- Do Reactive Oxygen and Nitrogen Species Have a Similar Effect on Digestive Processes in CarnivorousBiology · 2023Review
- Neuroprotective actions of a fatty acid nitroalkene in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Potential Therapeutic Value of the STING Inhibitors.Molecules (Basel, Switzerland) · 2023Review
- Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma.Frontiers in microbiomes · 2023Article
- Nitrated Fatty-Acids Distribution in Storage Biomolecules duringAntioxidants (Basel, Switzerland) · 2022Article
- Review
- Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease.The Journal of nutritional biochemistry · 2021Article
- Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONORedox biology · 2021Article
- Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids.Frontiers in pharmacology · 2021Article
- Electrophilic characteristics and aqueous behavior of fatty acid nitroalkenes.Redox biology · 2021Article
- Nitro-Oleic Acid in Seeds and Differently Developed Seedlings ofPlants (Basel, Switzerland) · 2020Article
- Data of detection and characterization of nitrated conjugated-linoleic acid (NOData in brief · 2020Article
- The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.Frontiers in pharmacology · 2020Review
- Exogenous Nitro-Oleic Acid Treatment Inhibits Primary Root Growth by Reducing the Mitosis in the Meristem inFrontiers in plant science · 2020Article
- Plant Unsaturated Fatty Acids: Multiple Roles in Stress Response.Frontiers in plant science · 2020Review
- Mechanisms and Role of Nitric Oxide in Phytotoxicity-Mitigation of Copper.Frontiers in plant science · 2020Review
- A concise appraisal of lipid oxidation and lipoxidation in higher plants.Redox biology · 2019Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 4 countries.
Funding
Abstract
Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophilic nitroalkene derivatives (NO2-FA) that manifest salutary pleiotropic cell signaling responses in mammals. Herein, the endogenous presence of NO2-FA in both EVOO and fresh olives was demonstrated by mass spectrometry. The electrophilic nature of these species was affirmed by the detection of significant levels of protein cysteine adducts of nitro-oleic acid (NO2-OA-cysteine) in fresh olives, especially in the peel. Further nitration of EVOO by NO2 (-) under acidic gastric digestive conditions revealed that human consumption of olive lipids will produce additional nitro-conjugated linoleic acid (NO2-cLA) and nitro-oleic acid (NO2-OA). The presence of free and protein-adducted NO2-FA in both mammalian and plant lipids further affirm a role for these species as signaling mediators. Since NO2-FA instigate adaptive anti-inflammatory gene expression and metabolic responses, these redox-derived metabolites may contribute to the cardiovascular benefits associated with the Mediterranean diet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.