ArticleLipids in health and disease2014
High-fat diet from perilla oil induces insulin resistance despite lower serum lipids and increases hepatic fatty acid oxidation in rats.
Article in Lipids in health and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Effects of Perilla Seed Oil on Blood Lipids, Oxidative Stress, and Inflammation in Hyperlipidemic Rats.Foods (Basel, Switzerland) · 2025Article
- Effects of dietary adjustment ofHeliyon · 2023Article
- The Genome of the Korean Island-OriginatedGenes · 2023Article
- Advances in Understanding the Genetic Basis of Fatty Acids Biosynthesis in Perilla: An Update.Plants (Basel, Switzerland) · 2022Review
- Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in Sprague-Dawley Rats Fed a High-Fat Diet.International journal of environmental research and public health · 2021Article
- Candidate gene screening for lipid deposition using combined transcriptomic and proteomic data from Nanyang black pigs.BMC genomics · 2021Article
- Assessment of potential human health risk due to heavy metal contamination in edible finfish and shellfish collected around Ennore coast, India.Environmental science and pollution research international · 2021Article
- Effect of vegetable oils with different fatty acid composition on high-fat diet-induced obesity and colon inflammation.Nutrition research and practice · 2020Article
- Pharmacokinetic and metabolomic analyses of Mangiferin calcium salt in rat models of type 2 diabetes and non-alcoholic fatty liver disease.BMC pharmacology & toxicology · 2020Article
- Twelve-month Studies onFoods (Basel, Switzerland) · 2020Article
- Data Independent Acquisition Mass Spectrometry Can Identify Circulating Proteins That Predict Future Weight Loss with a Diet and Exercise Programme.Journal of clinical medicine · 2019Article
- Effects of n-3 polyunsaturated fatty acids high fat diet intervention on the synthesis of hepatic high-density lipoprotein cholesterol in obesity-insulin resistance rats.Lipids in health and disease · 2016Article
- Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis.Scientific reports · 2015Article
- Fish oil supplementation alleviates depressant-like behaviors and modulates lipid profiles in rats exposed to chronic unpredictable mild stress.BMC complementary and alternative medicine · 2015Article
- Estrogen and n-3 polyunsaturated fatty acid supplementation have a synergistic hypotriglyceridemic effect in ovariectomized rats.Genes & nutrition · 2015Article
- Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.PloS one · 2014Article
- ELECTROACUPUNCTURE IMPROVES INSULIN SENSITIVITY IN HIGH-FAT DIET-INDUCED INSULIN RESISTANT RATS BY ACTIVATING SIRT1 AND GLUT4 IN QUADRICEPS FEMORIS.Acta endocrinologica (Bucharest, Romania : 2005)Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study is to investigate the effects of a high-fat diet from perilla oil on serum lipids, hepatic lipid metabolism and insulin sensitivity.
methodsMale Sprague-Dawley (SD) rats were fed either a control (CT) diet or a diet high in perilla oil (HP). After 16 weeks of feeding, the serum lipids were measured, and the gene expressions involved in hepatic fatty acid oxidation and synthesis were determined. In addition, hepatic fat deposition was detected, and insulin sensitivity was evaluated by means of euglycemic-hyperinsulinemic clamp.
resultsCompared with the rats in the CT group, the HP-feeding significantly decreased the levels of triglyceride (TG), total cholesterol (TCH) and HDL-cholesterol (HDL-c). HP-feeding did not change the levels of LDL-cholesterol (LDL-c), free fatty acid (FFA), intrahepatic lipids or body weight. Moreover, the HP-feeding dramatically increased the mRNA expressions of fatty acid oxidation markers (PPAR-alpha, CPT1A) and fatty acid synthesis markers (SREBP-1, FASN and ACC) in the liver. The HP-feeding induced increased protein levels of CPT1A, while reducing the protein levels of FASN and ACC in the liver. However, the glucose infusion rate significantly increased in the HP group compared with the CT group.
conclusionsOur data show that, in rats, excessive perilla oil intake may significantly lower serum lipids, strengthen hepatic fatty acid oxidation, and inhibit hepatic fatty acid synthesis, but at the same time may also lead to insulin resistance.
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