Evidence map›Paper›PMID 24152755›Full record

ReviewNutrients2013

The gluten-free diet: testing alternative cereals tolerated by celiac patients.

Isabel Comino, María de Lourdes Moreno, Ana Real, Alfonso Rodríguez-Herrera, Francisco Barro, Carolina Sousa

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 102 citations in OpenAlex.

  1. Assessment of Knowledge of Celiac Disease and Associated Conditions Among Dietitians in Jordan.International journal of environmental research and public health · 2025
    Article
  2. Article
  3. Review
  4. Development of Gluten-Free Bread Using Teosinte (Foods (Basel, Switzerland) · 2023
    Article
  5. Article
  6. A short update on new approaches to celiac disease.Acta bio-medica : Atenei Parmensis · 2022
    Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Assembly of the draft genome of buckwheat and its applications in identifying agronomically useful genes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Isabel CominoDepartamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Sevilla, c/Profesor García González 2, 41012 Sevilla, Spain. csoumar@us.es.
María de Lourdes Moreno
Ana Real
Alfonso Rodríguez-Herrera
Francisco Barro
Carolina Sousa
Universidad de Sevilla · ESInstituto de Agricultura Sostenible · ESInstituto Hispalense de Pediatria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A strict gluten-free diet (GFD) is the only currently available therapeutic treatment for patients with celiac disease, an autoimmune disorder of the small intestine associated with a permanent intolerance to gluten proteins. The complete elimination of gluten proteins contained in cereals from the diet is the key to celiac disease management. However, this generates numerous social and economic repercussions due to the ubiquity of gluten in foods. The research presented in this review focuses on the current status of alternative cereals and pseudocereals and their derivatives obtained by natural selection, breeding programs and transgenic or enzymatic technology, potential tolerated by celiac people. Finally, we describe several strategies for detoxification of dietary gluten. These included enzymatic cleavage of gliadin fragment by Prolyl endopeptidases (PEPs) from different organisms, degradation of toxic peptides by germinating cereal enzymes and transamidation of cereal flours. This information can be used to search for and develop cereals with the baking and nutritional qualities of toxic cereals, but which do not exacerbate this condition.

Indexed as

Diet, Gluten-FreeCeliac DiseaseEdible GrainGliadinHumansIntestine, SmallProlyl OligopeptidasesSerine EndopeptidasesGliadinPREPL protein, humanProlyl OligopeptidasesSerine Endopeptidases

Identifiers

PMID24152755
PMCPMC3820072
OpenAlexW2030810018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.