ArticleFrontiers in plant science2013
Pyrophosphate levels strongly influence ascorbate and starch content in tomato fruit.
Article in Frontiers in plant science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- COPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- From fruit growth to ripening in plantain: a careful balance between carbohydrate synthesis and breakdown.Journal of experimental botany · 2022Article
- Ascorbic Acid-The Little-Known Antioxidant in Woody Plants.Antioxidants (Basel, Switzerland) · 2019Review
- Mutagenesis Reveals That theFrontiers in plant science · 2019Article
- Putting primary metabolism into perspective to obtain better fruits.Annals of botany · 2018Review
- Vacuolar HThe Plant cell · 2018Article
- Inhibition of plastid PPase and NTT leads to major changes in starch and tuber formation in potato.Journal of experimental botany · 2018Article
- UDP-Sugar Producing Pyrophosphorylases: Distinct and Essential Enzymes With Overlapping Substrate Specificities, ProvidingFrontiers in plant science · 2018Review
- KONJAC1 and 2 Are Key Factors for GDP-Mannose Generation and Affect l-Ascorbic Acid and Glucomannan Biosynthesis in Arabidopsis.The Plant cell · 2015Article
- Sequence variation, differential expression, and divergent evolution in starch-related genes among accessions of Arabidopsis thaliana.Plant molecular biology · 2015Article
- Biofortification: how can we exploit plant science and biotechnology to reduce micronutrient deficiencies?Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascorbate (vitamin C) deficiency leads to low immunity, scurvy, and other human diseases and is therefore a global health problem. Given that plants are major ascorbate sources for humans, biofortification of this vitamin in our foodstuffs is of considerable importance. Ascorbate is synthetized by a number of alternative pathways: (i) from the glycolytic intermediates D-glucose-6P (the key intermediates are GDP-D-mannose and L-galactose), (ii) from the breakdown of the cell wall polymer pectin which uses the methyl ester of D-galacturonic acid as precursor, and (iii) from myo-inositol as precursor via myo-inositol oxygenase. We report here the engineering of fruit-specific overexpression of a bacterial pyrophosphatase, which hydrolyzes the inorganic pyrophosphate (PPi) to orthophosphate (Pi). This strategy resulted in increased vitamin C levels up to 2.5-fold in ripe fruit as well as increasing in the major sugars, sucrose, and glucose, yet decreasing the level of starch. When considered together, these finding indicate an intimate linkage between ascorbate and sugar biosynthesis in plants. Moreover, the combined data reveal the importance of PPi metabolism in tomato fruit metabolism and development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.