ArticlePloS one2013
Complete genes may pass from food to human blood.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 68 citations in OpenAlex.
- Beyond the Blood Cell: The Emerging Role of Cell-Free DNA in Transfusion Medicine.Journal of hematology · 2025Review
- Common microbial signatures in blood and their amplification in clinical disorders.Gut microbes reports · 2025Review
- Non-human primates as indicators of Kinetoplastida diversity in an urban environment in Midwest Brazil.Frontiers in parasitology · 2025Article
- Leptomeningeal Metastases in Melanoma Patients: An Update on and Future Perspectives for Diagnosis and Treatment.International journal of molecular sciences · 2023Review
- Old Methods, New Insights: Reviewing Concepts on the Ecology of Trypanosomatids andPathogens (Basel, Switzerland) · 2023Article
- Review
- Cell-Free DNA in the Pathogenesis and Therapy of Non-Infectious Inflammations and Tumors.Biomedicines · 2022Review
- Kinetoplastid Species Maintained by a Small Mammal Community in the Pantanal Biome.Pathogens (Basel, Switzerland) · 2022Article
- New Perspectives on the Importance of Cell-Free DNA Biology.Diagnostics (Basel, Switzerland) · 2022Review
- Formulation and Development of Bioadhesive Oral Films ContainingPharmaceutics · 2022Article
- The Influence of the Structure of Selected Polymers on Their Properties and Food-Related Applications.Polymers · 2022Review
- The influence of biological and lifestyle factors on circulating cell-free DNA in blood plasma.eLife · 2021Review
- 3D-Printed Drug Capture Materials Based on Genomic DNA Coatings.ACS applied materials & interfaces · 2021Article
- Properties and Application of Cell-Free DNA as a Clinical Biomarker.International journal of molecular sciences · 2021Review
- Towards systematic nomenclature for cell-free DNA.Human genetics · 2021Review
- Rapid diagnosis and comprehensive bacteria profiling of sepsis based on cell-free DNA.Journal of translational medicine · 2020Article
- Horizontal gene transfer in human-associated microorganisms inferred by phylogenetic reconstruction and reconciliation.Scientific reports · 2019Article
- Diverse RNA viruses of arthropod origin in the blood of fruit bats suggest a link between bat and arthropod viromes.Virology · 2019Article
- Bringing cultured meat to market: Technical, socio-political, and regulatory challenges in cellular agriculture.Trends in food science & technology · 2018Review
- Numerous uncharacterized and highly divergent microbes which colonize humans are revealed by circulating cell-free DNA.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples while non-plasma (cord blood) control sample was found to be free of plant DNA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.