Evidence map›Paper›PMID 23843441›Full record

SynthesisJournal of the National Cancer Institute2013

Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial.

Theodore M Brasky, Amy K Darke, Xiaoling Song, Catherine M Tangen, Phyllis J Goodman, Ian M Thompson, Frank L Meyskens, Gary E Goodman, Lori M Minasian, Howard L Parnes and 2 more

Open access · bronzeAbstract readMeta-AnalysisRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the National Cancer Institute, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 11 pooled it
37.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 11 syntheses or guidelines pooled it, 304 citations in OpenAlex.

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  5. Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease.The Cochrane database of systematic reviews · 2019
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Theodore M BraskyDepartment of Internal Medicine, Division of Cancer Prevention and Control, The Ohio State University College of Medicine, Columbus, OH, USA. Theodore.Brasky@osumc.edu
Amy K Darke
Xiaoling Song
Catherine M Tangen
Phyllis J Goodman
Ian M Thompson
Frank L Meyskens
Gary E Goodman
Lori M Minasian
Howard L Parnes
Eric A Klein
Alan R Kristal
Fred Hutch Cancer Center · USNational Institutes of Health · USUniversity of California, Irvine · USThe Ohio State University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Washington · US

Funding

SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
Cancer Prevention Trng-Nutrition, Exercise &GeneticsR25CA094880 · NCI · UNIVERSITY OF WASHINGTON · PI WHITE, EMILY · 2002 to 2016
$7.3M
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2M
NCI NIH HHS CA37429NCI NIH HHS R25 CA094880NCI NIH HHS R25-CA94880NCI NIH HHS U10 CA037429NCI NIH HHS UM1 CA182883
6 · The paper itself

Abstract

backgroundStudies of dietary ω-3 fatty acid intake and prostate cancer risk are inconsistent; however, recent large prospective studies have found increased risk of prostate cancer among men with high blood concentrations of long-chain ω-3 polyunsaturated fatty acids ([LCω-3PUFA] 20:5ω3; 22:5ω3; 22:6ω3]. This case-cohort study examines associations between plasma phospholipid fatty acids and prostate cancer risk among participants in the Selenium and Vitamin E Cancer Prevention Trial.

methodsCase subjects were 834 men diagnosed with prostate cancer, of which 156 had high-grade cancer. The subcohort consisted of 1393 men selected randomly at baseline and from within strata frequency matched to case subjects on age and race. Proportional hazards models estimated hazard ratios (HR) and 95% confidence intervals (CI) for associations between fatty acids and prostate cancer risk overall and by grade. All statistical tests were two-sided.

resultsCompared with men in the lowest quartiles of LCω-3PUFA, men in the highest quartile had increased risks for low-grade (HR = 1.44, 95% CI = 1.08 to 1.93), high-grade (HR = 1.71, 95% CI = 1.00 to 2.94), and total prostate cancer (HR = 1.43, 95% CI = 1.09 to 1.88). Associations were similar for individual long-chain ω-3 fatty acids. Higher linoleic acid (ω-6) was associated with reduced risks of low-grade (HR = 0.75, 95% CI = 0.56 to 0.99) and total prostate cancer (HR = 0.77, 95% CI = 0.59 to 1.01); however, there was no dose response.

conclusionsThis study confirms previous reports of increased prostate cancer risk among men with high blood concentrations of LCω-3PUFA. The consistency of these findings suggests that these fatty acids are involved in prostate tumorigenesis. Recommendations to increase LCω-3PUFA intake should consider its potential risks.

Indexed as

AgedCase-Control StudiesDietary SupplementsFatty Acids, Omega-3Fatty Acids, Omega-6HumansIncidenceMaleMiddle AgedNeoplasm GradingOdds RatioPhospholipidsProportional Hazards ModelsProspective StudiesProstatic NeoplasmsRisk AssessmentFatty Acids, Omega-3Fatty Acids, Omega-6PhospholipidsSeleniumVitamin E

Identifiers

PMID23843441
PMCPMC3735464
OpenAlexW2103708195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.