ArticleExperimental gerontology2013
Age-dependent mitochondrial energy dynamics in the mice heart: role of superoxide dismutase-2.
Article in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- A novel transdermal curcumin gel shows potential in improving cardiac bioenergetic functions in Berkeley sickle cell mice.Blood vessels, thrombosis & hemostasis · 2026Article
- Remote stimulation of mitochondria and the antioxidant potential of thymocytes by weak non-ionizing non-thermal broadband pulsed electromagnetic fields in mouse.Frontiers in physiology · 2026Article
- Antioxidant and Stress Resistance Properties of Flavonoids from Chinese Sea Buckthorn Leaves from the Qinghai-Tibet Plateau.Antioxidants (Basel, Switzerland) · 2024Article
- Ablation of Shank3 alleviates cardiac dysfunction in aging mice by promoting CaMKII activation and Parkin-mediated mitophagy.Redox biology · 2022Article
- Modeling the human heart ex vivo-current possibilities and strive for future applications.Journal of tissue engineering and regenerative medicine · 2022Review
- A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions.Frontiers in aging neuroscience · 2022Review
- Controlled power: how biology manages succinate-driven energy release.Biochemical Society transactions · 2021Article
- Increasing Fatty Acid Oxidation Prevents High-Fat Diet-Induced Cardiomyopathy Through Regulating Parkin-Mediated Mitophagy.Circulation · 2020Article
- Optimization and mechanism of postponing aging of polysaccharides from Chinese herbal medicine formula.Toxicology research · 2020Article
- Identification of Flavoanoids From Finger Citron and Evaluation on Their Antioxidative and Antiaging Activities.Frontiers in nutrition · 2020Article
- Mitochondrial quality control mechanisms as molecular targets in cardiac ageing.Nature reviews. Cardiology · 2018Review
- Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research.GeroScience · 2018Article
- Mitochondria and cardiovascular diseases-from pathophysiology to treatment.Annals of translational medicine · 2018Review
- UPRCell research · 2018Review
- Cerebrovascular pattern improved by ozone autohemotherapy: an entropy-based study on multiple sclerosis patients.Medical & biological engineering & computing · 2017Article
- Mitophagy plays a central role in mitochondrial ageing.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Assessing bioenergetic functions from isolated mitochondria in Drosophila melanogaster.Journal of biological methods · 2016Article
- Mitochondrial dysfunction in cardiac aging.Biochimica et biophysica acta · 2015Review
- Non-sirtuin histone deacetylases in the control of cardiac aging.Journal of molecular and cellular cardiology · 2015Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The aging process alters cardiac physiology, decreases the number of cardiomyocytes and alters the energy metabolism. Mitochondrial dysfunction in aging is believed to cause these functional and phenotypic changes in the heart. Although precise understanding of alterations of mitochondrial respiration in aging is necessary to manage heart diseases in the elderly population conflicting data on the function of specific complex of electron transport chain of the heart mitochondria limits the intervention process. We have addressed these issues using the assay of mitochondrial coupling and electron flow to assess specific functional defects in mitochondria isolated from young or aged mice. Our results demonstrate that cardiac mitochondria from older mice utilize oxygen at a decreased rate via complex I, II or IV compared to younger mice. We further show that mitochondrial function decreases in young Sod2(+/-) mice heart compared to young wildtype mice. However, the mitochondrial function remains unchanged in older Sod2(+/-) mice heart compared to younger Sod2(+/-) mice heart. Further, the oxygen consumption remains similar in old wildtype mice and old Sod2(+/-) mice heart mitochondria. The expression and activity of Sod2 in young or old Sod2(+/-) mice heart remain unchanged. These data demonstrate that decreased oxygen utilization in older age could have resulted in decreased mitochondrial ROS-mediated oxidative damage requiring less Sod2 for protection against mitochondrial oxidative stress in older wildtype or older Sod2(+/-) mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.