ArticleThe Journal of physiology2013
Taste responses in mice lacking taste receptor subunit T1R1.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 120 citations in OpenAlex.
- Effects and Mechanisms of Tastants on the Gustatory-Salivary Reflex in Human Minor Salivary Glands.BioMed research international · 2018Trial
- Clofibrate inhibits the umami-savory taste of glutamate.PloS one · 2017Trial
- Determining gene specificity from multivariate single-cell RNA sequencing data.bioRxiv : the preprint server for biology · 2025Article
- Dual functions of SNAP25 in mouse taste buds.The Journal of physiology · 2025Article
- Taste receptors and their ecological niches: cats, dogs, and other vertebrates.Chemical senses · 2025Review
- Effects of purine and pyrimidine 5'-ribonucleotides on glutamate detection threshold and umami intensity in Japanese young female trained participants.Chemical senses · 2025Article
- The role of GABA in modulation of taste signaling within the taste bud.Pflugers Archiv : European journal of physiology · 2024Article
- Taste Preferences in Broilers: Effect of Age, Delivery Matrix, and Number of Chickens per Pen on Selection and Consumption Behaviour.Animals : an open access journal from MDPI · 2024Article
- Ribonucleotides differentially modulate oral glutamate detection thresholds.Chemical senses · 2024Article
- Genetic Preference for Sweet Taste in Mothers Associates with Mother-Child Preference and Intake.Nutrients · 2023Article
- Diet Preference, Feed Efficiency and Expression of the Sodium-Dependent Glucose Transporter Isoform 1 and Sweet Taste Receptors in the Jejunum of Lambs Supplemented with Different Flavours.Animals : an open access journal from MDPI · 2023Article
- Conditioned Taste Aversion to L-Amino Acid Taste Stimuli and Oral Transcriptional Changes to Type 1 Taste Receptors T1R1 and T1R3 on Chronic Exposure to L-Alanine Solution in Chickens.The journal of poultry science · 2022Article
- Pharmacology of the Umami Taste Receptor.Handbook of experimental pharmacology · 2022Article
- Phosphatidylinositol-3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells.Journal of neurochemistry · 2021Article
- The umami receptor T1R1-T1R3 heterodimer is rarely formed in chickens.Scientific reports · 2021Article
- Taste transduction and channel synapses in taste buds.Pflugers Archiv : European journal of physiology · 2021Review
- Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue.Acta physiologica (Oxford, England) · 2020Article
- A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli.PLoS genetics · 2020Article
- Electrophysiological responses to sugars and amino acids in the nucleus of the solitary tract of type 1 taste receptor double-knockout mice.Journal of neurophysiology · 2020Article
- Differential effects of membrane sphingomyelin and cholesterol on agonist-induced bitter taste receptor T2R14 signaling.Molecular and cellular biochemistry · 2020Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The T1R1 receptor subunit acts as an umami taste receptor in combination with its partner, T1R3. In addition, metabotropic glutamate receptors (brain and taste variants of mGluR1 and mGluR4) are thought to function as umami taste receptors. To elucidate the function of T1R1 and the contribution of mGluRs to umami taste detection in vivo, we used newly developed knock-out (T1R1(-/-)) mice, which lack the entire coding region of the Tas1r1 gene and express mCherry in T1R1-expressing cells. Gustatory nerve recordings demonstrated that T1R1(-/-) mice exhibited a serious deficit in inosine monophosphate-elicited synergy but substantial residual responses to glutamate alone in both chorda tympani and glossopharyngeal nerves. Interestingly, chorda tympani nerve responses to sweeteners were smaller in T1R1(-/-) mice. Taste cell recordings demonstrated that many mCherry-expressing taste cells in T1R1(+/-) mice responded to sweet and umami compounds, whereas those in T1R1(-/-) mice responded to sweet stimuli. The proportion of sweet-responsive cells was smaller in T1R1(-/-) than in T1R1(+/-) mice. Single-cell RT-PCR demonstrated that some single mCherry-expressing cells expressed all three T1R subunits. Chorda tympani and glossopharyngeal nerve responses to glutamate were significantly inhibited by addition of mGluR antagonists in both T1R1(-/-) and T1R1(+/-) mice. Conditioned taste aversion tests demonstrated that both T1R1(-/-) and T1R1(+/-) mice were equally capable of discriminating glutamate from other basic taste stimuli. Avoidance conditioned to glutamate was significantly reduced by addition of mGluR antagonists. These results suggest that T1R1-expressing cells mainly contribute to umami taste synergism and partly to sweet sensitivity and that mGluRs are involved in the detection of umami compounds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.