ArticleThe American journal of tropical medicine and hygiene2013
High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Hepatitis E Virus (HEV) Infection in the Context of the One Health Approach: A Systematic Review.Pathogens (Basel, Switzerland) · 2025Pooled it
- Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis.BMC veterinary research · 2021Pooled it
- Emerging zoonotic viral infections of occupational health importance.Pathogens and disease · 2019Pooled it
- A systematic review of the epidemiology of hepatitis E virus in Africa.BMC infectious diseases · 2014Pooled it
- Current global estimates, risk factors, and knowledge gaps for Hepatitis E virus (HEV): A scoping review.PLoS neglected tropical diseases · 2026Article
- Hepatitis E Virus in the Role of an Emerging Food-Borne Pathogen.Microorganisms · 2025Review
- Epidemiology and seroprevalence of Hepatitis E Virus in Nigeria and its African context: a review and one health perspective.Le infezioni in medicina · 2025Review
- Hepatitis E Seroprevalence and Detection of Genotype 3 Strains in Domestic Pigs from Sierra Leone Collected in 2016 and 2017.Viruses · 2024Article
- Zoonotic and Food-Related Hazards Due to Hepatitis A and E in Africa: A Systematic Review and Meta-Analysis.Environmental health insights · 2024Review
- Investigating animal reservoirs for hepatitis E virus in Bangui, Central African Republic.PloS one · 2024Article
- Hepatitis E Virus in Livestock-Update on Its Epidemiology and Risk of Infection to Humans.Animals : an open access journal from MDPI · 2023Review
- Assessment on the efficacy of methods 2 to 5 and method 7 set out in Commission Regulation (EU) No 142/2011 to inactivate relevant pathogens when producing processed animal protein of porcine origin intended to feed poultry and aquaculture animals.EFSA journal. European Food Safety Authority · 2023Article
- Butchering activity is the main risk factor for hepatitis E virus (Frontiers in microbiology · 2023Article
- A scoping review of zoonotic parasites and pathogens associated with abattoirs in Eastern Africa and recommendations for abattoirs as disease surveillance sites.Frontiers in public health · 2023Article
- Characterization of a Near Full-Length Hepatitis E Virus Genome of Subtype 3c Generated from Naturally Infected South African Backyard Pigs.Pathogens (Basel, Switzerland) · 2022Article
- Nationwide survey of hepatitis E virus infection among wildlife in Japan.The Journal of veterinary medical science · 2022Article
- Hepatitis E seroprevalence and risk factors in humans and pig in Ghana.BMC infectious diseases · 2022Article
- Hepatitis E virus infection in pigs: a first report from Zambia.Emerging microbes & infections · 2021Article
- Porcine Blood and Liver as Sporadic Sources of Hepatitis E Virus (HEV) in the Production Chain of Offal-Derived Foodstuffs in Poland.Food and environmental virology · 2021Article
- Hepatitis E virus in professionally exposed: A reason for concern?World journal of hepatology · 2021Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) causes an orofecal disease transmitted through poor hygiene environments, contaminated food (mainly pork products), or by contacts with infected animals. Very little data are currently available regarding the disease in the Southwestern Indian Ocean Islands. We report the first sero- and viro-survey for HEV in human and swine in Madagascar. A seroprevalence rate of 14.1% (60 of 427) was measured in slaughterhouse workers. Seroprevalence to HEV in pigs was estimated to 71.2% (178 of 250), strongly suggesting the existence of a zoonotic cycle. Three out of 250 pig livers (1.2%) tested HEV RNA-positive by quantitative polymerase chain reaction. Phylogenetic analyses based on 1-kb sequences of the ORF 2-3 identified these viruses as HEV genotype 3. Sequences clustered in a distinct Malagasy sub-clade, possibly representative of a new sub-genotype, for which the date of emergence was estimated around 1989. Further studies are needed to confirm other transmission routes of HEV to humans, especially through non-zoonotic cycles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.