ArticleNutrition research and practice2012
Sorghum extract exerts an anti-diabetic effect by improving insulin sensitivity via PPAR-γ in mice fed a high-fat diet.
Article in Nutrition research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 73 citations in OpenAlex.
- Consumption of a drink containing extruded sorghum reduces glycaemic response of the subsequent meal.European journal of nutrition · 2018Trial
- Sorghum Promotes Cell Proliferation Through Activation of the Growth Hormone/IGF-1-JAK2/STAT5b Signaling AxisBiology · 2026Article
- The Germination Paradox in Sorghum: A Review.Foods (Basel, Switzerland) · 2026Review
- Sorghum and health: An overview of potential protective health effects.Journal of food science · 2024Review
- Article
- Leveraging the Potential of Sorghum as a Healthy Food and Resilient Crop in the South African Food System.Frontiers in sustainable food systems · 2022Article
- Article
- Impact of Gluten-Free Sorghum Bread Genotypes on Glycemic and Antioxidant Responses in Healthy Adults.Foods (Basel, Switzerland) · 2021Article
- Phenolic Compounds in Whole Grain Sorghum and Their Health Benefits.Foods (Basel, Switzerland) · 2021Review
- Effects of sorghum rice and black rice on genes associated with cholesterol metabolism in hypercholesterolemic mice liver and intestine.Food science & nutrition · 2021Article
- Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article.Frontiers in aging neuroscience · 2021Review
- Antiobesity and Antidiabetic Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Glycemic Index and Sensory Evaluation of Whole Grain Based Multigrain Indian Breads (Rotis).Preventive nutrition and food science · 2020Article
- Anti-Melanogenic Effect of Ethanolic Extract ofNutrients · 2020Article
- Network pharmacology of bioactives from Sorghum bicolor with targets related to diabetes mellitus.PloS one · 2020Article
- Plant-Based Diets in the Reduction of Body Fat: Physiological Effects and Biochemical Insights.Nutrients · 2019Review
- Triacylglycerol, fatty acid, and phytochemical profiles in a new red sorghum variety (Ji Liang No. 1) and its antioxidant and anti-inflammatory properties.Food science & nutrition · 2019Article
- Preadministration of Fermented Sorghum Diet Provides Protection against Hyperglycemia-Induced Oxidative Stress and Suppressed Glucose Utilization in Alloxan-Induced Diabetic Rats.Frontiers in nutrition · 2018Article
- Antihyperglycemic Effect ofIranian journal of pharmaceutical research : IJPR · 2017Article
- Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets.International journal of molecular sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the hypothesis that a sorghum extract exerts anti-diabetic effects through a mechanism that improves insulin sensitivity via peroxisome proliferator-activated receptor gamma (PPAR-γ) from adipose tissue. Seven C57BL/6 mice were fed an AIN-93M diet with fat consisting of 10% of total energy intake (LF) for 14 weeks, and 21 mice were fed a high-fat AIN diet with 60% of calories derived from fat (HF). From week 8, the HF diet-fed mice were orally administered either saline (HF group), 0.5% (0.5% SE group), or 1% sorghum extract (1% SE group) for 6 weeks (n = 7/group). Perirenal fat content was significantly lower in the 0.5% SE and 1% SE groups than that in the HF mice. Levels of total and low-density lipoprotein cholesterol, triglycerides, glucose, and the area under the curve for glucose were significantly lower in mice administered 0.5% SE and 1% SE than those in HF mice. Serum insulin level was significantly lower in mice administered 1% SE than that in HF mice or those given 0.5% SE. PPAR-γ expression was significantly higher, whereas the expression of tumor necrosis factor-α was significantly lower in mice given 1% SE compared to those in the HF mice. Adiponectin expression was also significantly higher in mice given 0.5% SE and 1% SE than that in the HF mice. These results suggest that the hypoglycemic effect of SE may be related with the regulation of PPAR-γ-mediated metabolism in this mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.