ArticleThe American journal of clinical nutrition2012
Urinary α-carboxyethyl hydroxychroman can be used as a predictor of α-tocopherol adequacy, as demonstrated in the Energetics Study.
Article in The American journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial.The American journal of clinical nutrition · 2017Trial
- α-Tocopherol bioavailability is lower in adults with metabolic syndrome regardless of dairy fat co-ingestion: a randomized, double-blind, crossover trial.The American journal of clinical nutrition · 2015Trial
- Identification and monitoring of metabolite markers of dry bean consumption in parallel human and mouse studies.Molecular nutrition & food research · 2015Trial
- Urinary α-Carboxyethyl Hydroxychromanol (α-CEHC)-A Biomarker of Vitamin E Intake: A Scoping Review.The Journal of nutrition · 2026Article
- Non-Linear Association of Relationship Between Serum Vitamin E and Eczema in US Adults.Food science & nutrition · 2025Article
- Scientific opinion on the tolerable upper intake level for vitamin E.EFSA journal. European Food Safety Authority · 2024Article
- Strategies to Enhance the Solubility and Bioavailability of Tocotrienols Using Self-Emulsifying Drug Delivery System.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Associations of 24 h urinary excretions of α- and γ-carboxyethyl hydroxychroman with plasma α- and γ-tocopherol and dietary vitamin E intake in older adults: the Lifelines-MINUTHE Study.European journal of nutrition · 2022Article
- Serum Metabolites Associated with Healthy Diets in African Americans and European Americans.The Journal of nutrition · 2021Article
- Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population.Antioxidants (Basel, Switzerland) · 2020Article
- Cardiovascular and Metabolic Protection by Vitamin E: A Matter of Treatment Strategy?Antioxidants (Basel, Switzerland) · 2020Review
- The balance between food and dietary supplements in the general population.The Proceedings of the Nutrition Society · 2019Article
- Stability of antioxidant vitamins in whole human blood during overnight storage at 4°C and frozen storage up to 6 months.International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2018Article
- Serum Metabolomic Response to Long-Term Supplementation withJournal of nutrition and metabolism · 2016Article
- Contribution of cod liver oil-related nutrients (vitamins A, D, E and eicosapentaenoic acid and docosahexaenoic acid) to daily nutrient intake and their associations with plasma concentrations in the EPIC-Norfolk cohort.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2015Article
- Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol.EFSA journal. European Food Safety Authority · 2015Article
- α-Tocopherol disappearance rates from plasma depend on lipid concentrations: studies using deuterium-labeled collard greens in younger and older adults.The American journal of clinical nutrition · 2015Article
- Changes in the concentrations of vitamin E analogs and their metabolites in rat liver and kidney after oral administration.Journal of clinical biochemistry and nutrition · 2015Article
- Article
- Vitamin E inadequacy in humans: causes and consequences.Advances in nutrition (Bethesda, Md.) · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOther than the in vitro erythrocyte hemolysis test, no valid biomarkers of vitamin E status currently exist.
objectiveWe hypothesized that the urinary vitamin E metabolite α-carboxyethyl hydroxychroman (α-CEHC) could serve as a biomarker.
designThe relations between urinary α-CEHC, plasma α-tocopherol, and vitamin E intakes were assessed by using a previously validated multipass, Web-based, 24-h self-administered dietary recall, and we concurrently collected plasma and 24-h urine samples from 233 participants of both sexes.
resultsMedian vitamin E intakes were 9.7 mg α-tocopherol/d. Intakes were correlated with plasma α-tocopherol (R = 0.40, P < 0.001) and urinary α-CEHC (R = 0.42, P < 0.001); these correlations were essentially unchanged after multivariate adjustments. On the basis of multiple regression analysis, urinary α-CEHC excretion increased by ~0.086 μmol/g creatinine (95% CI: 0.047, 0.125) for every 1-mg (2.3-μmol) increase in dietary α-tocopherol. Urinary α-CEHC excretion remained at a plateau (median: 1.39 μmol/g creatinine) until dietary intakes of α-tocopherol exceeded 9 mg α-tocopherol/d. The inflection point at which vitamin E metabolism increased was estimated to be at an intake of 12.8 mg α-tocopherol/d. Daily excretion of >1.39 μmol α-CEHC/g creatinine is associated with a greater than adequate α-tocopherol status, as evidenced by increased vitamin E metabolism and excretion.
conclusionThus, urinary α-CEHC is a valid biomarker of α-tocopherol status that can be used to set a value for the Estimated Adequate Requirement of vitamin E.
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