Trial reportEuropean journal of clinical nutrition2012
Neural effects of green tea extract on dorsolateral prefrontal cortex.
Trial report in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.Nutrients · 2020Trial
- L-theanine-targeted prefrontal cortex improves CUMS-induced depression via the gut-short-chain fatty acids-brain axis.NPJ science of food · 2025Article
- Promising, but Not Completely Conclusive-The Effect of l-Theanine on Cognitive Performance Based on the Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Trials.Journal of clinical medicine · 2025Review
- Moderate tea consumption and dementia-related neuroimaging markers.Frontiers in neurology · 2025Article
- Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients.Sports medicine (Auckland, N.Z.) · 2022Review
- Effect of Daily Intake of Green Tea Catechins on Cognitive Function in Middle-Aged and Older Subjects: A Randomized, Placebo-Controlled Study.Molecules (Basel, Switzerland) · 2020Article
- Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline.Current nutrition reports · 2018Review
- The Effects of Green Tea Extract on Working Memory in Healthy Women.The journal of nutrition, health & aging · 2018Article
- Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging.Neural plasticity · 2017Review
- Polyphenols Beyond Barriers: A Glimpse into the Brain.Current neuropharmacology · 2017Review
- A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action.Nutrients · 2015Review
- Green tea polyphenols and their potential role in health and disease.Inflammopharmacology · 2015Review
- Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?Current neuropharmacology · 2014Article
- Green tea extract enhances parieto-frontal connectivity during working memory processing.Psychopharmacology · 2014Article
- Polyphenols and the human brain: plant “secondary metabolite” ecologic roles and endogenous signaling functions drive benefits.Advances in nutrition (Bethesda, Md.) · 2014Review
- Understanding the Neurobiological Mechanisms of Green Tea in Modulating Cognitive Function in Neurodegenerative Disorders: A Narrative Review.Innovations in clinical neuroscienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesGreen tea is being recognized as a beverage with potential benefits for human health and cognitive functions. In vivo studies provide preliminary evidence that green tea intake may have a positive role in improving effects on cognitive functions. We aimed to examine the neural effects of green tea extract on brain activation in humans. SUBJECTS/
methodsFunctional magnetic resonance imaging was recorded while 12 healthy volunteers performed a working memory task following administration of 250 or 500 ml of a milk whey based green tea containing soft drink or milk whey based soft drink without green tea as control in a double-blind, controlled repeated measures within-subject design with counterbalanced order of substance administration. A whole-brain analysis with a cluster-level threshold of P<0.001 (unadjusted) was followed by an a priori-defined region of interest (ROI) analysis of the dorsolateral prefrontal cortex (DLPFC) including a cluster-level threshold of P<0.05 and family-wise error (FWE) adjustment for multiple comparisons.
resultsWhole-brain analyses revealed no significant effects after correction for multiple comparisons (FWE P<0.05). Using a ROI approach, green tea extract increased activation in the DLPFC relative to a control condition (FWE P<0.001). This neural effect was related to green tea dosage. Green tea extract was not associated with any significant attenuation in regional activation relative to control condition.
conclusionsThese data suggest that green tea extract may modulate brain activity in the DLPFC, a key area that mediates working memory processing in the human brain. Moreover, this is the first neuroimaging study implicating that functional neuroimaging methods provide a means of examining how green tea extract acts on the brain.
Indexed as
Identifiers
22929964What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.