ArticlePloS one2012
Associations between apolipoprotein E genotype, diet, body mass index, and serum lipids in Lithuanian adult population.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- One Diet Does Not Fit All: A Systematic Review and Meta-Analysis of Gene-Diet Interactions Affecting Blood Lipid Profiles.Current issues in molecular biology · 2026Review
- Assessing Orthorexic Tendencies and Dietary Patterns: A Cross-Sectional Study of Orthorexia Nervosa and Dietary Patterns in Lithuania.Nutrients · 2026Article
- The independent association between 25 (OH) vitamin D deficiency, HOMA-IR, and lipid profile with APOE genotyping in obese cases with and without T2DM.Diabetology & metabolic syndrome · 2024Article
- Association betweenInternational journal of molecular sciences · 2022Article
- Article
- Association of Cardiovascular Risk Factors and APOE Polymorphism with Mortality in the Oldest Old: A 21-Year Cohort Study.Arquivos brasileiros de cardiologia · 2020Article
- Lack of association between genetic variants in the 19q13.32 region and CHD risk in the Algerian population: a population-based nested case-control study.African health sciences · 2020Article
- Impact ofPharmacogenomics and personalized medicine · 2020Article
- Phenotype and genotype predictors of BMI variability among European adults.Nutrition & diabetes · 2018Article
- Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors.Lipids in health and disease · 2018Article
- Poststroke Depression Biomarkers: A Narrative Review.Frontiers in neurology · 2018Review
- Late-Life Body Mass Index, Rapid Weight Loss, Apolipoprotein E ε4 and the Risk of Cognitive Decline and Incident Dementia.The journal of nutrition, health & aging · 2017Article
- Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4.International journal of obesity (2005) · 2016Article
- Apolipoprotein E genotyping and questionnaire-based assessment of lifestyle risk factors in dyslipidemic patients with a family history of Alzheimer's disease: test development for clinical application.Metabolic brain disease · 2016Article
- Effects of Soy Flour Fortified Bread Consumption on Cardiovascular Risk Factors According to APOE Genotypes in Overweight and Obese Adult Women: A Cross-over Randomized Controlled Clinical Trial.Clinical nutrition research · 2015Article
- Influence of APOE-2 genotype on the relation between adiposity and plasma lipid levels in patients with vascular disease.International journal of obesity (2005) · 2015Article
- Selenium Level and Dyslipidemia in Rural Elderly Chinese.PloS one · 2015Article
- The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men.PloS one · 2014Article
- What We Know About Diet, Genes, and Dyslipidemia: Is There Potential for Translation?Current nutrition reports · 2013Article
- Impact of APOE gene polymorphisms on the lipid profile in an Algerian population.Lipids in health and disease · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundApolipoprotein E (APOE) polymorphism is associated with lipid levels. Some studies have reported that blood lipid response to diet or obesity varies depending on APOE genotypes. The aim of this study was to assess the effect of APOE genotypes, the intake of saturated fatty acids (SFA), and obesity on serum lipid levels in Lithuanian adult population. METHODOLOGY/PRINCIPAL
findingsA cross-sectional health survey was carried out in five municipalities of Lithuania. The random sample was obtained from lists of 25-64 year-old inhabitants registered at primary health care centres. The data from 996 subjects (416 men and 580 women) were analysed in this study. Two single-nucleotide polymorphisms (rs429358 and rs7412) were assessed using a real-time polymerase chain reaction. 24-hour recall and food frequency questionnaire were used for evaluation of dietary habits. Serum lipids were determined using enzymatic methods. Men and women with the APOE2 genotype had the lowest level of total cholesterol (TC) (p = 0.002 for men, and p = 0.02 for women) and low-density lipoprotein cholesterol (LDL-C) (p<0.001). Multivariate linear regression analysis showed that age, genotype APOE2, SFA intake, and body mass index (BMI) were significant determinants of TC and LDL-C level (with p values ranging from 0.043 to 0.001). Our data did not reveal any statistically significant interactions between APOE genotype and SFA intake or between APOE genotype and BMI regarding TC and LDL-C level (all p>0.05). However, the predictive power of the regression model for LDL-C improved when gene-BMI interaction and gene-BMI interaction plus gene-nutrient interaction were added (p = 0.04 and p = 0.032 for R(2) change, respectively). CONCLUSIONS/SIGNIFICANCE: APOE genotypes, SFA intake, and obesity were found to be associated with blood lipid levels in Lithuanian adult population. Analysis of gene-diet and gene-obesity interactions did not confirm that the effects of diet and obesity on TC and LDL-C level significantly depended on APOE genotype.
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