ReviewSeminars in immunopathology2012
Mucosal antibodies in the regulation of tolerance and allergy to foods.
Review in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- A randomized, double-blind, placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow's milk allergy.The Journal of allergy and clinical immunology · 2016Trial
- Viral infections in celiac disease: what should be considered for better management.Clinical and experimental medicine · 2024Review
- Feeding Docosahexaenoic Acid and Arachidonic Acid during Suckling and Weaning Contributes to Oral Tolerance Development by Beneficially Modulating the Intestinal Cytokine and Immunoglobulin Levels in an Allergy-Prone Brown Norway Rat Model.The Journal of nutrition · 2024Article
- Antibodies in breast milk: Pro-bodies designed for healthy newborn development.Immunological reviews · 2024Review
- All roads lead to IgA: Mapping the many pathways of IgA induction in the gut.Immunological reviews · 2024Review
- Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.The Journal of allergy and clinical immunology · 2024Article
- Metabolic fitness of IgAMucosal immunology · 2024Article
- Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.Science translational medicine · 2022Article
- Study of the effect of intestinal immunity in neonatal piglets coinfected with porcine deltacoronavirus and porcine epidemic diarrhea virus.Archives of virology · 2022Article
- The Gut Microbiome and the Big Eight.Nutrients · 2020Review
- Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization.Science immunology · 2020Article
- Free Amino Acids in Human Milk: A Potential Role for Glutamine and Glutamate in the Protection Against Neonatal Allergies and Infections.Frontiers in immunology · 2020Review
- Recent developments in understanding the mechanisms of food allergy.Current opinion in pediatrics · 2019Review
- Diet and Immune Function.Nutrients · 2019Article
- Oral Tolerance Development and Maintenance.Immunology and allergy clinics of North America · 2018Review
- Peculiarities of the formation and subsequent removal of the circulating immune complexes from the bloodstream during the process of digestion.F1000Research · 2018Article
- Introduction of various allergenic foods during infancy reduces risk of IgE sensitization at 12 months of age: a birth cohort study.Pediatric research · 2017Article
- Gut Microbiome and the Development of Food Allergy and Allergic Disease.Pediatric clinics of North America · 2015Review
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- IgE-based Immunotherapy of Cancer -A Comparative Oncology Approach.Journal of carcinogenesis & mutagenesis · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The intestinal mucosa is densely packed with antibody-secreting B cells, the majority of which produce IgA. Mucosal antibodies have traditionally been thought of as neutralizing antibodies that exclude antigens, but they also function in antigen sampling, allowing for selective transcytosis of antigens from the intestinal lumen. IgE-mediated antigen uptake can facilitate the development of allergic reactions to foods, but emerging evidence indicates that IgG-mediated antigen uptake may also play an important role in the development of immune tolerance to foods, particularly in the neonate. This review will focus on the role of intestinal immunoglobulins in the development of clinical tolerance and allergy to food antigens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.