ArticlePloS one2012
DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- A Systematic Review of the Balloon Analogue Risk Task (BART) in Alcohol Research.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022Pooled it
- Preliminary evidence for normalization of risk taking by modafinil in chronic cocaine users.Addictive behaviors · 2014Trial
- Distinctive Neural Substrates of low and high Risky Decision Making: Evidence from the Balloon Analog Risk Task.Brain topography · 2024Article
- Decomposing risky decision-making in methamphetamine use disorder: Behavioral updating and D2 dopamine receptors.Drug and alcohol dependence · 2023Article
- Risky decision-making strategies mediate the relationship between amygdala activity and real-world financial savings among individuals from lower income households: A pilot study.Behavioural brain research · 2022Article
- A Bayesian method for measuring risk propensity in the Balloon Analogue Risk Task.Behavior research methods · 2022Article
- Emotional-Behavioral Regulation, Temperament and Parent-Child Interactions Are Associated with Dopamine Transporter Allelic Polymorphism in Early Childhood: A Pilot Study.International journal of environmental research and public health · 2020Article
- Personality and Genetics Correlations to Risk-Taking Using Quantum Decision Theory in Balloon Analogue Risk Tasks.Cureus · 2020Review
- Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population.CNS neuroscience & therapeutics · 2020Article
- Dopamine Related Genes Differentially Affect Declarative Long-Term Memory in Healthy Humans.Frontiers in behavioral neuroscience · 2020Article
- Predicting risk decisions in a modified Balloon Analogue Risk Task: Conventional and single-trial ERP analyses.Cognitive, affective & behavioral neuroscience · 2018Article
- Insensitivity to response-contingent feedback in adolescents with developmental language disorder (DLD).Brain and language · 2017Article
- A genetic marker of risk in HIV-infected individuals with a history of hazardous drinking.AIDS care · 2017Observational
- Adaptive Adolescent Flexibility: Neurodevelopment of Decision-making and Learning in a Risky Context.Journal of cognitive neuroscience · 2017Article
- The effects of DAT1 genotype on fMRI activation in an emotional go/no-go task.Brain imaging and behavior · 2017Article
- Genetically-Driven Enhancement of Dopaminergic Transmission Affects Moral Acceptability in Females but Not in Males: A Pilot Study.Frontiers in behavioral neuroscience · 2017Article
- Dynamic interaction between fetal adversity and a genetic score reflecting dopamine function on developmental outcomes at 36 months.PloS one · 2017Article
- Transactional Links Between Teacher-Student Relationships and Adolescent Rule-Breaking Behavior and Behavioral School Engagement: Moderating Role of a Dopaminergic Genetic Profile Score.Journal of youth and adolescence · 2016Article
- Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twin-studies suggest that a significant portion of individual differences in the propensity to take risks resides in people's genetic make-up and there is evidence that variability in dopaminergic systems relates to individual differences in risky choice. We examined the link between risk taking in a risk taking task (the Balloon Analogue Risk Task, BART) and a variable number tandem repeat (VNTR) polymorphism in the 3'UTR of the dopamine transporter gene (SLC6A3/DAT1). Behavior in BART is known to be associated with activity in striatal reward-processing regions, and DAT1 is assumed to modulate striatal dopamine levels. We find that carriers of DAT1 alleles, which presumably result in lower striatal dopamine availability, showed more risk taking, relative to carriers of the alleles associated with higher striatal dopamine availability. Our analyses suggest that the mechanism underlying this association is diminished sensitivity to rewards among those who take more risks. Overall, our results support the notion that a behavioral genetic approach can be helpful in uncovering the basis of individual differences in risk taking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.