ArticleJournal of agricultural and food chemistry2012
Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.
Article in Journal of agricultural and food chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
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Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 399 citations in OpenAlex.
- Effects of Grape Seed Proanthocyanidin Extract on Obesity.Obesity facts · 2020Pooled it
- Postprandial effects of a polyphenolic grape extract (PGE) supplement on appetite and food intake: a randomised dose-comparison trial.Nutrition journal · 2015Trial
- Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study.Scientific reports · 2015Trial
- Flavonoid constituents contribute to the low diastase activity ofFood chemistry: X · 2026Article
- Plant by-products as a valuble source of natural antiglycemic compounds: Economic aspects and alternative raw material sources.Journal of food and drug analysis · 2026Review
- Proanthocyanidin-Rich Cranberry Extract Lowers Glycemia in Established Obesity by Delaying Glucose Absorption.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Valorization and Functional Enhancement of Mature Assam Tea Leaves Through Indigenous Filamentous Fungi-Based Fermentation for Functional Drink Development.Foods (Basel, Switzerland) · 2026Article
- Structure-effect relationship of phenolic compounds onCurrent research in food science · 2026Article
- Nutritional and Functional Values of Grape Seed Flour and Extract for Production of Antioxidative Dietary Supplements and Functional Foods.Molecules (Basel, Switzerland) · 2025Article
- Applying Isothermal Titration Calorimetry and Saturation Transfer Difference-NMR to Study the Mode of Interaction of Flavan-3-ols with α-Amylase to Understand Their Impact on Starch Hydrolysis.Journal of agricultural and food chemistry · 2025Article
- Natural Products and Diabetes: (-)-Epicatechin and Mechanisms Involved in the Regulation of Insulin Sensitivity.Handbook of experimental pharmacology · 2025Review
- Epigenetic repurposing of carbohydrate metabolic inhibitors for insulin resistance: targeting DNMT1 and HDAC3 for β-cell restoration.Frontiers in epigenetics and epigenomics · 2025Review
- The Antidiabetic Effect of Grape Skin Extracts of Selected Indigenous Croatian White Grapevine Varieties.Foods (Basel, Switzerland) · 2024Article
- Grape Pomace as a Source of Phenolics for the Inhibition of Starch Digestion Enzymes: A Comparative Study and Standardization of the Efficacy.Foods (Basel, Switzerland) · 2024Article
- Phytochemical Analysis, Biological Activities, and Docking of Phenolics from Shoot Cultures ofMolecules (Basel, Switzerland) · 2024Article
- Polyphenols mediated attenuation of diabetes associated cardiovascular complications: A comprehensive review.Journal of diabetes and metabolic disorders · 2024Review
- Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus.Heliyon · 2024Review
- Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review.Food science & nutrition · 2024Review
- Probing the binding mechanism of tea polyphenols from different processing methods to anti-obesity and TMAO production-related enzymes throughFood chemistry: X · 2024Article
- Phytochemicals-linked food safety and human health protective benefits of the selected food-based botanicals.PloS one · 2024Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
This study evaluated the inhibitory effects of plant-based extracts (grape seed, green tea, and white tea) and their constituent flavan-3-ol monomers (catechins) on α-amylase and α-glucosidase activity, two key glucosidases required for starch digestion in humans. To evaluate the relative potency of extracts and catechins, their concentrations required for 50 and 90% inhibition of enzyme activity were determined and compared to the widely used pharmacological glucosidase inhibitor, acarbose. Maximum enzyme inhibition was used to assess relative inhibitory efficacy. Results showed that grape seed extract strongly inhibited both α-amylase and α-glucosidase activity, with equal and much higher potency, respectively, than acarbose. Whereas tea extracts and catechin 3-gallates were less effective inhibitors of α-amylase, they were potent inhibitors of α-glucosidase. Nongallated catechins were ineffective. The data show that plant extracts containing catechin 3-gallates, in particular epigallocatechin gallate, are potent inhibitors of α-glucosidase activity and suggest that procyanidins in grape seed extract strongly inhibit α-amylase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.