ArticleThe Journal of antimicrobial chemotherapy2012
Antimicrobial effect of diallyl sulphide on Campylobacter jejuni biofilms.
Article in The Journal of antimicrobial chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
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- Effect of glutathione-transport-related geneApplied and environmental microbiology · 2024Article
- Antimicrobial Efficacy of Phyto-L, Thiosulfonate fromVeterinary sciences · 2023Article
- Ability of Garlic and Ginger Oil to ReduceAnimals : an open access journal from MDPI · 2022Article
- Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies.Molecules (Basel, Switzerland) · 2022Article
- Effect of aromatic oils on the expression of some virulence-associated and antimicrobial resistance genes ofJournal of advanced veterinary and animal research · 2022Article
- Rapid, Label-Free Prediction of Antibiotic Resistance inInternational journal of molecular sciences · 2022Article
- Antibiofilm Effects of Heated Scallop Shell Powder onMembranes · 2021Article
- Review
- Antimicrobial Resistance Gene Transfer from Campylobacter jejuni in Mono- and Dual-Species Biofilms.Applied and environmental microbiology · 2021Article
- Campylobacter jejuni Antimicrobial Resistance Profiles and Mechanisms Determined Using a Raman Spectroscopy-Based Metabolomic Approach.Applied and environmental microbiology · 2021Article
- Article
- Antibacterial Properties of Organosulfur Compounds of Garlic (Frontiers in microbiology · 2021Review
- Select Phytochemicals ReduceFrontiers in microbiology · 2021Article
- Anti-biofilm activity of garlic extract loaded nanoparticles.Nanomedicine : nanotechnology, biology, and medicine · 2019Article
- Article
- Characterization of the Desiccation Tolerance ofFrontiers in microbiology · 2018Article
- A Negative Regulator of Cellulose Biosynthesis,Frontiers in microbiology · 2017Article
- Intrinsic and Extrinsic Aspects onFrontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesBacterial biofilms pose significant food safety risks because of their attachment to fomites and food surfaces, including fresh produce surfaces. The purpose of this study was to systematically investigate the activity of selected antimicrobials on Campylobacter jejuni biofilms.
methodsC. jejuni biofilms and planktonic cells were treated with ciprofloxacin, erythromycin and diallyl sulphide and examined using infrared and Raman spectroscopies coupled with imaging analysis.
resultsDiallyl sulphide eliminated planktonic cells and sessile cells in biofilms at a concentration that was at least 100-fold less than used for either ciprofloxacin or erythromycin on the basis of molarity. Distinct cell lysis was observed in diallyl sulphide-treated planktonic cells using immunoblot analysis and was confirmed by a rapid decrease in cellular ATP. Two phases of C. jejuni biofilm recalcitrance modes against ciprofloxacin and erythromycin were validated using vibrational spectroscopies: (i) an initial hindered adsorption into biofilm extracellular polymeric substance (EPS) and delivery of antibiotics to sessile cells within biofilms; and (ii) a different interaction between sessile cells in a biofilm compared with their planktonic counterparts. Diallyl sulphide destroyed the EPS structure of the C. jejuni biofilm, after which the sessile cells were killed in a similar manner as planktonic cells. Spectroscopic models can predict the survival of sessile cells within biofilms.
conclusionsDiallyl sulphide elicits strong antimicrobial activity against planktonic and sessile C. jejuni and may have applications for reducing the prevalence of this microbe in foods, biofilm reduction and, potentially, as an alternative chemotherapeutic agent for multidrug-resistant bacterial strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.