Evidence map›Paper›PMID 22461076›Full record

ArticleHepatology (Baltimore, Md.)2012

The TONIC trial: a step forward in treating pediatric nonalcoholic fatty liver disease.

Naim Alkhouri, Ariel E Feldstein

Abstract readComment
In one paragraph

Article in Hepatology (Baltimore, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. [Construction norms for the tiered diagnosis and treatment and standardized management center of metabolic-associated fatty liver disease].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Guideline
  2. Trial
  3. Trial
  4. MASLD In Children - A Distinct Phenotype?Current obesity reports · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Observational
  9. Treatment of non-alcoholic fatty liver disease - Current perspectives.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020
    Review
  10. Non-Alcoholic Fatty Liver Disease, an Overview.Integrative medicine (Encinitas, Calif.) · 2019
    Review
  11. Omega-3 for nonalcoholic fatty liver disease in children.Canadian family physician Medecin de famille canadien · 2019
    Article
  12. Article
  13. Frontiers in pharmacology · 2017
    Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Naim AlkhouriDepartment of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, USA.
Ariel E Feldstein

Funding

Caspase Dependent Cell Death in Nonalcoholic Fatty Liver DiseaseR01DK082451 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL · 2009 to 2012
$1.4M
The Lysosomal-Mitochondrial Axis in Nonalcoholic Fatty Liver DiseaseR01DK076852 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FELDSTEIN, ARIEL · 2007 to 2011
$1.4M
NIDDK NIH HHS DK076852NIDDK NIH HHS R01 DK076852NIDDK NIH HHS R01 DK082451
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID22461076
PMCPMC3325147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.