← Metformin × liver & masld

TrialJAMA2011

Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.

Joel E Lavine et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 173 people · 2011

Randomised comparison

Probably lowered liver & MASLD

−35.2U/L−56.9 to −13.5

As reported

difference −35.2 U/L, 95% CI −56.9 to −13.5

One number in the abstract

the abstract, start to end

… ALT level from baseline to 96 weeks was -35.2 U/L (95% CI, -56.9 to -13.5) …

← favours treatmentfavours comparator →
could be chance
Liver & masld
−35.2−56.9 to −13.5
MetforminSupplements & botanicalsLiver & MASLD

Metformin × liver & masldhelps?one trial

unlikelylikely
0.500.25 without it

Supplements & botanicals × liver & masldhelps?one trial

unlikelylikely
0.50only evidence
← favours treatmentfavours comparator →
this papermore certainless certain
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The trial

Full record →Abstract, authors, funding and every citing paper · PMID 21521847