Trial reportThe Journal of urology2012
Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial.
Trial report in The Journal of urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Conservative interventions for treating urinary incontinence in women: an Overview of Cochrane systematic reviews.The Cochrane database of systematic reviews · 2022Pooled it
- Lifestyle interventions for the treatment of urinary incontinence in adults.The Cochrane database of systematic reviews · 2015Pooled it
- The relationship between early weight loss and weight loss at 1 year with naltrexone ER/bupropion ER combination therapy.International journal of obesity (2005) · 2016Trial
- Impact of intensive lifestyle intervention on preference-based quality of life in type 2 diabetes: Results from the Look AHEAD trial.Obesity (Silver Spring, Md.) · 2016Trial
- Long-term prevalence and predictors of urinary incontinence among women in the Diabetes Prevention Program Outcomes Study.International journal of urology : official journal of the Japanese Urological Association · 2015 · on this mapTrial
- Implications of Look AHEAD for clinical trials and clinical practice.Diabetes, obesity & metabolism · 2014Trial
- Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial.The lancet. Diabetes & endocrinology · 2014Trial
- Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: results from the Look AHEAD trial.The Journal of urology · 2014Trial
- Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.The New England journal of medicine · 2013Trial
- Article
- Impact of weight loss on the risk of urinary incontinence: the role of sex and body type.World journal of urology · 2024Article
- Protocol for a prospective longitudinal cohort study on the effects of non-surgical weight loss on pelvic floor dysfunction.BMJ open · 2024Article
- Development and Validation of a Risk Prediction Model for Female Stress Urinary Incontinence in Rural Fujian, China.Risk management and healthcare policy · 2024Article
- Help-seeking behavior for nonsevere stress urinary incontinence among elderly women in communities, Beijing, China.International urogynecology journal · 2023Article
- Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms and Aging and Major Chronic Diseases.Frontiers in medicine · 2022Review
- Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations.Diabetes & metabolism journal · 2020Review
- Article
- Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome.Journal of the American Geriatrics Society · 2018Review
- Obesity and Stress Urinary Incontinence: Impact on Pathophysiology and Treatment.Current urology reports · 2018Review
- Weight Loss and Improvement in Comorbidity: Differences at 5%, 10%, 15%, and Over.Current obesity reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
purposeWe determined the effect of weight loss on the prevalence, incidence and resolution of weekly or more frequent urinary incontinence in overweight/obese women with type 2 diabetes after 1 year of intervention in the Look AHEAD (Action for Health in Diabetes) trial. MATERIALS AND
methodsWomen in this substudy (2,739, mean ± SD age 57.9 ± 6.8 years, body mass index 36.5 ± 6.1 kg/m(2)) were randomized into an intensive lifestyle weight loss intervention or a diabetes support and education control condition.
resultsAt baseline 27% of participants reported urinary incontinence on a validated questionnaire (no significant difference by intensive lifestyle intervention vs diabetes support and education). After 1 year of intervention the intensive lifestyle intervention group in this substudy lost 7.7 ± 7.0 vs 0.7 ± 5.0 kg in the diabetes support and education group. At 1 year fewer women in the intensive lifestyle intervention group reported urinary incontinence (25.3% vs 28.6% in the diabetes support and education group, p = 0.05). Among participants without urinary incontinence at baseline 10.5% of intensive lifestyle intervention and 14.0% of diabetes support and education participants experienced urinary incontinence after 1 year (p = 0.02). There were no significant group differences in the resolution of urinary incontinence (p >0.17). Each kg of weight lost was associated with a 3% reduction in the odds of urinary incontinence developing (p = 0.01), and weight losses of 5% to 10% reduced these odds by 47% (p = 0.002).
conclusionsModerate weight loss reduced the incidence but did not improve the resolution rates of urinary incontinence at 1 year among overweight/obese women with type 2 diabetes. Weight loss interventions should be considered for the prevention of urinary incontinence in overweight/obese women with diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.