Evidence map›Paper›PMID 22218819›Full record

ArticlePrimary care respiratory journal : journal of the General Practice Airways Group2012

Statin use in COPD patients is associated with a reduction in mortality: a national cohort study.

Carlene M M Lawes, Simon Thornley, Robert Young, Raewyn Hopkins, Roger Marshall, Wing Cheuk Chan, Gary Jackson

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In one paragraph

Article in Primary care respiratory journal : journal of the General Practice Airways Group, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
  7. Review
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  11. Observational
  12. Review
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  14. Disconnection of pulmonary and systemic arterial stiffness in COPD.International journal of chronic obstructive pulmonary disease · 2018
    Article
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  16. Article
  17. Review
  18. Review
  19. Emerging pharmaceutical therapies for COPD.International journal of chronic obstructive pulmonary disease · 2017
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Carlene M M LawesClinical Trials Research Unit, University of Auckland, Auckland, New Zealand. c.lawes@ctru.auckland.ac.nz
Simon Thornley
Robert Young
Raewyn Hopkins
Roger Marshall
Wing Cheuk Chan
Gary Jackson

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo assess whether statin use is associated with reduced mortality in patients with chronic obstructive pulmonary disease (COPD).

methodsHospitalisation, drug dispensing, and mortality records were linked for New Zealanders aged 50-80 years discharged from hospital with a first admission with COPD in 2006. Patients were classified according to whether or not they were prescribed statins prior to admission. Baseline characteristics were compared and hazard ratios calculated for statin users versus statin non-users for all-cause mortality over follow-up of up to 4 years.

resultsA total of 1,687 patients (mean age 70.6 years) were followed, including 596 statin users and 1,091 non-users. There were more men in the statin user group (58.4% vs. 48.5%), and statin users were more likely to have a history of cardiovascular disease (58.6% vs. 25.1%), prescription for frusemide as a proxy for heart failure (47.7% vs. 24.5%) or diabetes (35.4% vs.11.6%) than statin non-users (p<0.001). A total of 671 deaths occurred during the follow-up period. After adjustment for age, sex, ethnic group, history of cardiovascular disease, diabetes, and prescription for frusemide, the hazard ratio for statin users vs. statin non-users for all-cause mortality was 0.69 (95% CI 0.58 to 0.84).

conclusionsStatin use is associated with a 30% reduction in all-cause mortality at 3-4 years after first admission for COPD, irrespective of a past history of cardiovascular disease and diabetes.

Indexed as

AgedAtorvastatinCardiovascular DiseasesCohort StudiesDiabetes MellitusFemaleFollow-Up StudiesHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMedical Record LinkageMiddle AgedNew ZealandPulmonary Disease, Chronic ObstructivePyrrolesAtorvastatinHeptanoic AcidsHydroxymethylglutaryl-CoA Reductase InhibitorsPyrrolesSimvastatin

Identifiers

PMID22218819
PMCPMC6547889

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Texttitle and abstract
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.